The results showed that there was significant association between <i>MTR</i> A2756G polymorphism and risk of pediatric ALL</span> in overall population (AG vs. AA: OR = 1.13, 95%CI = 1.02-1.26, <i>P</i> = 0.02; AG+GG vs. AA: OR = 1.13, 95%CI = 1.02-1.25, <i>P</i> = 0.01; G allele vs. A allele: OR = 1.10, 95%CI = 1.01-1.20, <i>P</i> = 0.03).
Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C1420T, TYMS 5´-UTR 2R3R, TYMS 3´-UTR ins6/del6, MTHFR C677T, MTR A2756G polymorphisms using PCR-RFLP and PCR-amplified fragment length polymorphism techniques.