rs1805087, MTR

N. diseases: 135
Disease: Neural Tube Defects ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Neural Tube Defects
CUI: C0027794
Disease: Neural Tube Defects
0.090 GeneticVariation BEFREE The BHMT gene rs3733890, RFC1 gene rs1051266 and MTR gene rs1805087 were associated with the occurrence of NTDs in Han population of Northern China. 28770393 2018
Neural Tube Defects
CUI: C0027794
Disease: Neural Tube Defects
0.090 GeneticVariation BEFREE Furthermore, the result of the meta-analysis supported the association between MTRR 66A>G and NTDs risk (G allele vs. A allele: OR = 1.32, 95% CI = 1.09-1.61, GG + GA vs. AA: OR = 1.49, 95% CI = 1.06-2.09, GG vs. AA: OR = 1.61, 95% CI = 1.04-2.49).Our study confirmed that the MTRR 66A>G and MTR 2756A>G were significantly associated with the increased NTDs risk in a Chinese population. 26334892 2015
Neural Tube Defects
CUI: C0027794
Disease: Neural Tube Defects
0.090 GeneticVariation BEFREE The present meta-analysis indicated that MTRR A66G polymorphism, but not MTR A2756G, is significantly associated with maternal risk for NTDs in Caucasians. 23266814 2013
Neural Tube Defects
CUI: C0027794
Disease: Neural Tube Defects
0.090 GeneticVariation BEFREE To sum up, no associations between the MTR A2756G polymorphism and NTD risk were found among the 3 groups in all genetic models. 23438943 2013
Neural Tube Defects
CUI: C0027794
Disease: Neural Tube Defects
0.090 GeneticVariation BEFREE Interaction between maternal 5,10-methylenetetrahydrofolate reductase C677T and methionine synthase A2756G gene variants to increase the risk of fetal neural tube defects in a Shanxi Han population. 23489792 2013
Neural Tube Defects
CUI: C0027794
Disease: Neural Tube Defects
0.090 GeneticVariation BEFREE The present meta-analyses indicate that MTR A2756G and MTRR A66G polymorphism are not associated with NTD risks in Caucasian children. 23425389 2013
Neural Tube Defects
CUI: C0027794
Disease: Neural Tube Defects
0.090 GeneticVariation BEFREE No significant NTD association was found with S175L or K350R in cases or their parents and no interactions were observed between these polymorphisms and the D919G variant of MTR or the A222V variant of 5,10-methylenetetrahydrofolate reductase (MTHFR). 15979034 2005
Neural Tube Defects
CUI: C0027794
Disease: Neural Tube Defects
0.090 GeneticVariation BEFREE We detected MTR A2756G and MTRR A66G polymorphisms using PCR-RFLP analysis in a group of NTD infants, their mothers and normal controls. 12649067 2003
Neural Tube Defects
CUI: C0027794
Disease: Neural Tube Defects
0.090 GeneticVariation BEFREE The D919G mutation does not seem to be a risk factor for NTD or vascular disease. 9327029 1997