rs1805087, MTR

N. diseases: 135
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.080 GeneticVariation BEFREE Logistic regression analysis after applying factorial design to the studied single nucleotide polymorphisms (SNPs) revealed that homocysteine levels and heterozygous and mutant alleles at rs1801133, rs1805087, along with mutant alleles at rs1801131, rs4646994, conferred higher risk for CAD. 28514598 2017
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.080 GeneticVariation BEFREE To investigate the association between 3 major polymorphisms in genes encoding enzymes involved in remethylation of homocysteine to methionine--methionine synthase (MTR) A2756G, methionine synthase reductase (MTRR) A66G, and betaine homocysteine methyltransferase (BHMT) G742A--and CAD, with assessment of small-study bias and differences between studies. 22339686 2012
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.080 GeneticVariation BEFREE Logistic regression, after adjusting for covariates, demonstrated significant associations of rs1801133 and rs1805087 with CAD in the additive, dominant, and genotype model. 21567207 2011
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.080 GeneticVariation BEFREE In contrast, the association of the substitutions A2756G of methionine synthase (MTR), A66G of methionine synthase reductase (MTRR) and C776G of transcobalamin (TCN) to both t-Hcys and CAD needs to be evaluated further. 16268464 2005
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.080 GeneticVariation BEFREE We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes [methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C; methionine synthase (MS) A2756G; methionine synthase reductase (MTRR) A66G] in relation to total plasma Hcy levels, transplant coronary artery disease and thromboembolic episodes in 84 heart transplant patients, and we compared the incidence of these polymorphisms with those in a healthy adult controls. 15612980 2005
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.080 GeneticVariation BEFREE The 2756A>G variant in the gene encoding methionine synthase: its relation with plasma homocysteine levels and risk of coronary heart disease in a Dutch case-control study. 12893022 2003
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.080 GeneticVariation BEFREE Our results suggest that neither single mutation nor combined mutations in MTHFR C677T, CBS 844ins68 and MS A2756G represent an independent risk factor for increasing IS and coronary artery disease risks in Chinese population. 11672761 2001
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.080 GeneticVariation BEFREE Methyltetrahydrofolate reductase (MTHFR) 677C-->T, cystathionine beta synthase (CBS) 68-bp insertion at exon 8, and methionine synthase (MS) 2756A-->G were typed in 685 Australian caucasian patients aged < or =65 years with and without angiographically documented coronary artery disease (CAD). 10487496 1999