Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the present meta-analysis indicated that MTRR rs1801394, MTR rs1805087, and MTHFR rs1801133 polymorphisms could be used to identify individuals at high risk of developing BC.
|
31549463 |
2020 |
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the present meta-analysis indicated that MTRR rs1801394, MTR rs1805087, and MTHFR rs1801133 polymorphisms could be used to identify individuals at high risk of developing BC.
|
31549463 |
2020 |
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTR c.2756A>G polymorphism may confer protection for BC associated with iAs exposure.
|
28889078 |
2017 |
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTR c.2756A>G polymorphism may confer protection for BC associated with iAs exposure.
|
28889078 |
2017 |
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development.
|
27173331 |
2016 |
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development.
|
27173331 |
2016 |
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
SHMT C1420T mutations may reduce breast cancer susceptibility, whereas MTRR A66G and MS A2756G mutations may increase breast cancer susceptibility.
|
27347936 |
2016 |
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
SHMT C1420T mutations may reduce breast cancer susceptibility, whereas MTRR A66G and MS A2756G mutations may increase breast cancer susceptibility.
|
27347936 |
2016 |
Complete Trisomy 21 Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
The case-control study revealed association of the polymorphism with increased folate levels, and a possible interaction with the methionine synthase (MTR) c.2756A>G one, that resulted in a borderline significant maternal risk of birth of a child with DS for the double heterozygous MTR 2756AG/MTRR 66AG genotype [OR 1.79 (95 % CI 1.00-3.18)].
|
24965145 |
2014 |
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We did not find a significant effect of the MTHFR A1298C and MTR A2756G on the risk of breast cancer.
|
25366783 |
2014 |
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
We did not find a significant effect of the MTHFR A1298C and MTR A2756G on the risk of breast cancer.
|
25366783 |
2014 |
Down Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
The case-control study revealed association of the polymorphism with increased folate levels, and a possible interaction with the methionine synthase (MTR) c.2756A>G one, that resulted in a borderline significant maternal risk of birth of a child with DS for the double heterozygous MTR 2756AG/MTRR 66AG genotype [OR 1.79 (95 % CI 1.00-3.18)].
|
24965145 |
2014 |
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This case-control study found that the MTHFR C677T and MTR A2756G polymorphisms are associated with risk of breast cancer, and folate, vitamin B6, and vitamin B12 intakes influence these associations.
|
25217320 |
2014 |
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
This case-control study found that the MTHFR C677T and MTR A2756G polymorphisms are associated with risk of breast cancer, and folate, vitamin B6, and vitamin B12 intakes influence these associations.
|
25217320 |
2014 |
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the findings suggest that MTR A2756G polymorphism is not associated with altered susceptibility to breast cancer, while the observed decreased risk in Caucasians, PB subgroup, and large studies and increased risk in small studies may be due to selection bias or other unknown factors.
|
23845785 |
2013 |
Complete Trisomy 21 Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Therefore, we carried out a meta-analysis of 26, 17, 9, 15, 9 and 6 case-control studies on the relationship between maternal methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, methionine synthase reductase (MTRR) A66G, reduced folate carrier 1 A80G and cystathionine β-synthase 844ins68 polymorphisms and the risk of having a DS offspring.
|
24068460 |
2013 |
Down Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Therefore, we carried out a meta-analysis of 26, 17, 9, 15, 9 and 6 case-control studies on the relationship between maternal methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, methionine synthase reductase (MTRR) A66G, reduced folate carrier 1 A80G and cystathionine β-synthase 844ins68 polymorphisms and the risk of having a DS offspring.
|
24068460 |
2013 |
Complete Trisomy 21 Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Present data do not support a role for MTR 2756A>G as independent maternal risk factor for a DS birth.
|
24150725 |
2013 |
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the findings suggest that MTR A2756G polymorphism is not associated with altered susceptibility to breast cancer, while the observed decreased risk in Caucasians, PB subgroup, and large studies and increased risk in small studies may be due to selection bias or other unknown factors.
|
23845785 |
2013 |
Down Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Present data do not support a role for MTR 2756A>G as independent maternal risk factor for a DS birth.
|
24150725 |
2013 |
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this case-control study, we investigated the association between MTHFR C677T and A1298C, TYMS 5'-UTR, MTR A2756G and cSHMT C1420T and also the folate carrier (RFC1 G80A) and breast cancer risk in a northeastern Brazilian population.
|
22134752 |
2012 |
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study points out the importance of the interactions between the MTHFR C677T, MTHFR A1298C and MTR A2756G polymorphisms, and also highlights the relevance of the MTR A2756G polymorphism and age in breast cancer risk.
|
23155246 |
2012 |
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study points out the importance of the interactions between the MTHFR C677T, MTHFR A1298C and MTR A2756G polymorphisms, and also highlights the relevance of the MTR A2756G polymorphism and age in breast cancer risk.
|
23155246 |
2012 |
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this case-control study, we investigated the association between MTHFR C677T and A1298C, TYMS 5'-UTR, MTR A2756G and cSHMT C1420T and also the folate carrier (RFC1 G80A) and breast cancer risk in a northeastern Brazilian population.
|
22134752 |
2012 |
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Taken together, the results suggest that the MTR A2756G polymorphism may contribute to susceptibility to breast cancer among Europeans.
|
20111902 |
2010 |