|
recurrent muscle twitches (symptom)
|
|
0.010 |
GeneticVariation
|
BEFREE |
Together with the common KCNE1 variant S38G, previously proposed as a genetic modifier of AF, HCN4-P883R may provide a substrate for the development of AF and TIC.
|
31481236 |
2019 |
|
Tic disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Together with the common KCNE1 variant S38G, previously proposed as a genetic modifier of AF, HCN4-P883R may provide a substrate for the development of AF and TIC.
|
31481236 |
2019 |
|
Behavioral tic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Together with the common KCNE1 variant S38G, previously proposed as a genetic modifier of AF, HCN4-P883R may provide a substrate for the development of AF and TIC.
|
31481236 |
2019 |
|
Cardiac Arrhythmia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Patients with KCNE1(G38S) had a rate-dependent repolarization abnormality similar to patients with LQT2 and, therefore, may have a potential risk to develop lethal arrhythmias.
|
27255646 |
2017 |
|
Long Qt Syndrome 2
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the QT-RR regression lines, the QT-RR slope was greater in the KCNE1(G38S) carriers and the LQT2 patients (0.215 ± 0.021 and 0.207 ± 0.032, respectively) than in the LQT1 patients (0.163 ± 0.014, P < 0.05) and the control subjects (0.135 ± 0.025, P < 0.001).
|
27255646 |
2017 |
|
Congenital long QT syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicate that the novel KCNH2-C108Y variant can be a pathogenic LQTS mutation, whereas KCNQ1-p.R583H, KCNH2-p.K897T, and KCNE1-p.G38S could be LQTS modifiers.
|
28749435 |
2017 |
|
Long QT Syndrome 1
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the QT-RR regression lines, the QT-RR slope was greater in the KCNE1(G38S) carriers and the LQT2 patients (0.215 ± 0.021 and 0.207 ± 0.032, respectively) than in the LQT1 patients (0.163 ± 0.014, P < 0.05) and the control subjects (0.135 ± 0.025, P < 0.001).
|
27255646 |
2017 |
|
Torsades de Pointes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Abnormal repolarization dynamics in a patient with KCNE1(G38S) who presented with torsades de pointes.
|
26520166 |
2016 |
|
Ventricular arrhythmia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Patients with KCNE1(G38S) could have similar potential risk of ventricular arrhythmia as with LQTS.
|
26520166 |
2016 |
|
Kidney Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, rs1805127, in KCNE1, is associated with the presence of nephropathy.
|
27509294 |
2016 |
|
Tinnitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
After adjustment, rs426496 was significantly associated with tinnitus during the initial crisis and with altered electronystagmography, and rs1805127 was significantly associated with nephropathy.
|
27509294 |
2016 |
|
Meniere Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
A polymorphism rs1805127 in the potassium channel gene, KCNE1, was associated with MD in sporadic (p = 0.011), but not familial patients (p = 0.62).
|
22934933 |
2012 |
|
Heart failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
KCNE1 S38G SNP is associated with HF predisposition in two study populations.
|
20185111 |
2010 |
|
Congestive heart failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
KCNE1 S38G SNP is associated with HF predisposition in two study populations.
|
20185111 |
2010 |
|
Premature ventricular contractions
|
|
0.010 |
GeneticVariation
|
BEFREE |
H558R was associated with an increase in QT dispersion (QTd) at minimum and maximum heart rate and QT interval prolongation before premature ventricular beats (PVB), whereas S38G and intronic polymorphisms were related to an increase in QTd before PVB.
|
18803136 |
2008 |
|
Long QT Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
Although KCNE1(G38S), a single-nucleotide polymorphism (SNP) causing a G38S substitution in KCNE1, is found frequently, whether and how this SNP causes long QT syndrome (LQTS) remains unclear.
|
27255646 |
2017 |
|
Long QT Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
Patients with KCNE1(G38S) could have similar potential risk of ventricular arrhythmia as with LQTS.
|
26520166 |
2016 |
|
Atrial Fibrillation
|
|
0.100 |
GeneticVariation
|
BEFREE |
Together with the common KCNE1 variant S38G, previously proposed as a genetic modifier of AF, HCN4-P883R may provide a substrate for the development of AF and TIC.
|
31481236 |
2019 |
|
Atrial Fibrillation
|
|
0.100 |
GeneticVariation
|
BEFREE |
The G38S polymorphism in the KCNE1 gene can significantly increase the risk of AF in both Chinese and white.
|
28640127 |
2017 |
|
Atrial Fibrillation
|
|
0.100 |
GeneticVariation
|
BEFREE |
The incidence of AF among the senior Uygur population in Xinjiang territory was correlated with the KCNE1 (G38S) polymorphism, which may be an independent risk factor for Uygur AF patients.
|
26662381 |
2015 |
|
Atrial Fibrillation
|
|
0.100 |
GeneticVariation
|
BEFREE |
KCNE1 112G>A may be useful as a biomarker for predicting the development of AF.
|
25366730 |
2014 |
|
Atrial Fibrillation
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study confirmed the association of the 112G>A polymorphism and postoperative AF in a cohort of patients undergoing cardiac surgery.
|
24439990 |
2014 |
|
Atrial Fibrillation
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs1805127 polymorphism (A>G) of KCNE1 is associated with an increased risk of AF, which suggests the rs1805217 polymorphism of KCNE1 gene may play an important role in the pathogenesis of AF.
|
23874724 |
2013 |
|
Atrial Fibrillation
|
|
0.100 |
GeneticVariation
|
BEFREE |
KCNE1 G38S genetic polymorphism was determined between 237 non-valvular atrial fibrillation cases and 237 control subjects using PCR-RFLP.
|
23129484 |
2012 |
|
Atrial Fibrillation
|
|
0.100 |
GeneticVariation
|
BEFREE |
We also found that rs1805127 was associated with left atrial diameter and left ventricular end diastolic diameter in AF patients (χ(2)=24.883, p<0.001; χ(2)=34.901, p<0.001, respectively).
|
23020083 |
2012 |