rs1805192, PPARG

N. diseases: 121
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE Diabetes genomics research has illuminated single nucleotide polymorphism (SNP) in several genes including, fat mass and obesity associated (FTO) (rs9939609 and rs9926289), potassium voltage-gated channel subfamily J member 11 (rs5219), SLC30A 8 (rs13266634) and peroxisome proliferator-activated receptor gamma 2 (rs1805192). 31823921 2019
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa. 24447396 2014
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE The interaction of the PPARγ Pro12Ala polymorphism with diabetes and cardiovascular risk is controversial. 22017455 2012
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE There was no convincing association between any polymorphism of PPARα and PPARγ and each individual component of the metabolic syndrome, except for the relationship of the P12A polymorphism with diabetes. 21877956 2012
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE Another PPARγ polymorphism, the C1431T, is in strong linkage disequilibrium with Pro12Ala and has been shown to be associated with body weight, but its association with diabetes is controversial. 21795447 2011
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE Our findings shows the association of these two polymorphisms with serum triglyceride levels, which was increased in the order of P12P-CC < P12P-CT < P12A-CC < P12A-CT in the CHD patients with diabetes. 21833536 2011
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE The authors highlight these challenges and biases using an illustrative example: meta-analysis of interactions between the Pro12Ala variant of the peroxisome proliferator-activated receptor gamma (PPARgamma) gene and various diet and lifestyle factors in the risk of diabetes. 20406760 2010
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE The Pro12Ala variant in the peroxisome proliferator-activated receptor gamma (PPARG) gene has been associated with diabetes and several cancers. 19436234 2009
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE Studies on the association of the Pro12Ala and C1431T polymorphisms of PPAR? with diabetes and obesity have revealed extensive population-dependent variations. 19805902 2009
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE Genetic polymorphism of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala on ethnic susceptibility to diabetes in Uygur, Kazak and Han subjects. 17941898 2008
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE The data did suggest that risk of cognitive decline is greater when Pro12A</span>la carriers contract diabetes. 18280041 2008
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer. 17763950 2008
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE The P12A variant of isoform gamma is estimated to reduce diabetes risk by 19% in many populations, and has a large attributable risk because of high prevalence of the normal allele. 18388689 2008
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been associated with decreased risk of diabetes and obesity, both disorders linked to cognitive impairment. 17052804 2008
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE The role of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma in diabetes risk. 17563457 2007
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE We tested the effect-modifying role of Pro12Ala on the 1 year change in obesity-related traits in a randomised clinical trial of treatment with metformin (n = 989), troglitazone (n = 363) or lifestyle modification (n = 1,004) vs placebo (n = 1,000) for diabetes prevention in high-risk individuals. 17898990 2007
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE Adiponectin values did not differ among these two genotypes even when categorized based on their diabetes status (normal glucose tolerance Pro12Pro 7.9 vs. Pro12Ala 7.7 microg/ml, P = 0.994; diabetes Pro12Pro 4.7 vs. Pro12Ala 5.4 microg/ml, P = 0.622). 17335469 2007
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE The proline allele at PPARG P12A increases risk for diabetes in persons with impaired glucose tolerance, an effect modified by body mass index. 17213274 2007
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE PPARG P12A (rs1801282) was not significantly associated with diabetes or related traits. 17903298 2007
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE The genetic influence of PPARG P12A genotype is modest and is overshadowed by duration of diabetes and systolic blood pressure as the major risk factors for diabetic nephropathy in the Oji-Cree population. 17493550 2007
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE There appears to be certain genes which predispose Indians to diabetes while other genes (for example Pro 12 Ala polymorphism of PPAR gamma gene) which afford protection against diabetes and insulin resistance to Caucasians, do not appear to protect Indians. 17496355 2007
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer. 16393309 2006
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE Across all studies, the Pro12Ala polymorphism had no significant effect on diabetes-related traits. 17065690 2006
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE Cumulative rather than synergistic effects of PPARG Pro12Ala and APM1 SNPs on diabetes risk are suggested. 16567542 2006
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE There were significant associations of the Pro12Ala single nucleotide polymorphism (SNP) genotypes with diabetes in both case-control comparisons (P=0.025 and P=0.039). 16401314 2005