Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Albeit small, our study may suggest that other pathways in AT or effects exerted in other tissues might contribute to the Pro12Ala-mediated protection against T2D. 30064293 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE These findings suggest no significant association of p.Pro12Ala polymorphism with retinopathy in tested type 2 diabetic retinopathy patients as compared to T2DM individuals take as controls. 27427939 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE We found a significant association of Pro12Ala polymorphism of PPARγ2 gene with T2DM, however the genotypes showed statistically significant association only with few clinical parameters including body mass index, total cholesterol, and low-density lipoprotein (P < 0.05). 27567620 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Our results support an important association between rs1805192 and rs3856806 minor allele (G allele) of PPARG and increased T2DM risk, the interaction analysis shown a combined effect of G- obesity interaction between rs1805192 and obesity on increased T2DM risk. 28123453 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE We genotyped PPARγ Pro12Ala polymorphism in subjects with type 2 diabetes mellitus (T2DM). 26836268 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Effect of the PPARG2 Pro12Ala Polymorphism on Associations of Physical Activity and Sedentary Time with Markers of Insulin Sensitivity in Those with an Elevated Risk of Type 2 Diabetes. 25974167 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Variation in PPARG, but not Pro12Ala, contributes to declining SI and concomitant deterioration in β-cell function in Mexican Americans at risk for T2DM. 25584717 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE In rare families, loss-of-function (LOF) mutations in PPARG are known to cosegregate with lipodystrophy and insulin resistance; in the general population, the common P12A variant is associated with a decreased risk of type 2 diabetes (T2D). 25157153 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE We investigated the independent and joint effects of PPARG Pro12Ala</span> and IRS1 Gly972Arg on markers of insulin resistance and T2DM in an African population with elevated risk of T2DM.</span> 24447396 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Hence, our aim was to develop a low-cost method for the validation of PPARG (Pro12Ala, CCA>GCA) SNP (rs1801282) for its association with T2D. 25063576 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The association between PPARG Pro12Ala SNP and increased T2D susceptibility was confirmed, with Pro12 as risk allele. 23386649 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Meanwhile PPARG-2 Pro12Ala, CDKN2A/2B rs10811661, IGF2BP2 rs4402960, HHEX rs7923837, CDKAL1 rs7754840, EXT2 rs1113132 and SLC30A8 rs13266634 were found to have no significant association with T2D among Arabs. 23458876 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE A total of 180 subjects with DR, 193 subjects with type 2 diabetes mellitus (T2DM) with no diabetic retinopathy, and 200 healthy normoglycemic non-retinopathic Pakistani individuals were genotyped for the rs1801282 (c.34C>G) polymorphism using polymerase chain reaction-restriction fragment length polymorphism. 23559865 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Pro12Ala mutation decreases PPARG activity and resistance to NIDDM. 22937051 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE In the case-control analysis, PPARG rs1801282 (Pro12Ala) (OR=1.48 (1.02-2.16)), ADIPOQ rs1063539 (OR=1.17 (1.01-1.35)), and HNF4A rs1884614 (OR=1.16 (1.00-1.32) were associated with T2D (P(allelic)<0.05). 22515931 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Our aim was to study the interaction effect between PPARγ gene (PPARG) polymorphisms Pro12Ala and 1431C>T and fat intake on incident T2D and BMI in a 9-year prospective cohort drawn from the French general population, the D.E.S.I.R. 21540831 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE In fact, we evaluated the effect of seven polymorphisms in the following genes-PPARg (Pro12Ala), TNFα (-308A/G), ENPP1(K121Q), TCF7L2(rs7903146°C/T), MTHFR(C677T), ACE(I/D), and CAPN10(3R/2R)-on T2D risk, through a meta-analysis combining data of previous studies performed on Tunisian populations originating from the north, center, or south of the country. 23249316 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Peroxisome proliferator-activated receptor gamma (PPARG) Pro12Ala polymorphism and its reported relationship to type 2 diabetes susceptibility and body mass accumulation prompted us to investigate the impact of this single nucleotide polymorphism (SNP) on antipsychotic-induced changes of body weight and body mass index (BMI) in a naturalistic study design. 22413765 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Is it time to conduct a hypothesis-driven large-scale exercise training intervention trial based on PPARγ Pro12Ala</span> genotype with T2DM-related phenotypes as the primary outcome measures, while also assessing potential mechanistic changes in skeletal muscle and adipose tissue? 22672138 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE In conclusion, we found that men with type 2 diabetes having the Ala-isoform of PPARγ Pro12Ala had an unfavorable cardiovascular risk profile, whereas women with this isoform had lower carotid-radial PWV and higher apolipoprotein A1 levels suggesting a beneficial prognosis. 22017455 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Peroxisome proliferator-activated receptor γ polymorphism Pro12Ala Is associated with nephropathy in type 2 diabetes: evidence from meta-analysis of 18 studies. 22619290 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The protective role of the Ala allele in the Pro12Ala polymorphism of PPARγ on type 2 diabetes has been well established but not confirmed in the context of pregnancy, for gestational diabetes, a known predictor of later type 2 diabetes onset. 21795447 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Polymorphism of peroxisome proliferator-activated receptor γ (PPARγ) Pro12Ala in the Iranian population: relation with insulin resistance and response to treatment with pioglitazone in type 2 diabetes. 21968139 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Effects of the PPARG P12A and C161T gene variants on serum lipids in coronary heart disease patients with and without Type 2 diabetes. 21833536 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The Pro12Ala polymorphism in the PPAR-gamma gene has been associated with reduced incidence of type 2 diabetes. 18639367 2010