Primary malignant neoplasm
|
|
0.080 |
GeneticVariation
|
BEFREE |
In carriers of 657del5 deletion, the cancer risk was restricted to men with the GG genotype of the E185Q variant of the same gene.
|
30590007 |
2019 |
Primary malignant neoplasm
|
|
0.080 |
GeneticVariation
|
BEFREE |
In carriers of the 657del5 deletion, the elevated cancer risk was restricted to women with the GG genotype of the E185Q variant (OR = 3.6, 95% CI 1.9-6.6; p < 0.0001).
|
31410679 |
2019 |
Malignant Neoplasms
|
|
0.080 |
GeneticVariation
|
BEFREE |
In carriers of 657del5 deletion, the cancer risk was restricted to men with the GG genotype of the E185Q variant of the same gene.
|
30590007 |
2019 |
Malignant Neoplasms
|
|
0.080 |
GeneticVariation
|
BEFREE |
In carriers of the 657del5 deletion, the elevated cancer risk was restricted to women with the GG genotype of the E185Q variant (OR = 3.6, 95% CI 1.9-6.6; p < 0.0001).
|
31410679 |
2019 |
Primary malignant neoplasm
|
|
0.080 |
GeneticVariation
|
BEFREE |
In human NBS1 (hNBS1), Q185E polymorphism is known as the factor to cancer risks, although its DSB repair defect has not been addressed.
|
28107384 |
2017 |
Malignant Neoplasms
|
|
0.080 |
GeneticVariation
|
BEFREE |
In human NBS1 (hNBS1), Q185E polymorphism is known as the factor to cancer risks, although its DSB repair defect has not been addressed.
|
28107384 |
2017 |
Malignant Neoplasms
|
|
0.080 |
GeneticVariation
|
BEFREE |
In conclusion, current evidence did not suggest that the NBS1 Glu185Gln polymorphism was associated with overall cancer risk, but this polymorphism might contribute to the risk for some specific cancer sites due to potential different mechanisms.
|
23979977 |
2014 |
Primary malignant neoplasm
|
|
0.080 |
GeneticVariation
|
BEFREE |
The meta-analysis further confirmed the association between the variant rs1805794G>C and lung cancer risk, that compared with the GG genotype, the carriers of C genotypes had a 1.30-fold risk of cancer (95% CI=1.14-1.49, P=8.49×10(-5)).
|
25771871 |
2014 |
Primary malignant neoplasm
|
|
0.080 |
GeneticVariation
|
BEFREE |
In conclusion, current evidence did not suggest that the NBS1 Glu185Gln polymorphism was associated with overall cancer risk, but this polymorphism might contribute to the risk for some specific cancer sites due to potential different mechanisms.
|
23979977 |
2014 |
Malignant Neoplasms
|
|
0.080 |
GeneticVariation
|
BEFREE |
The meta-analysis further confirmed the association between the variant rs1805794G>C and lung cancer risk, that compared with the GG genotype, the carriers of C genotypes had a 1.30-fold risk of cancer (95% CI=1.14-1.49, P=8.49×10(-5)).
|
25771871 |
2014 |
Primary malignant neoplasm
|
|
0.080 |
GeneticVariation
|
BEFREE |
However, rs1805794, D95N and P266L did not appear to have an effect on cancer risk.
|
24113799 |
2013 |
Primary malignant neoplasm
|
|
0.080 |
GeneticVariation
|
BEFREE |
The NBS1 Glu185Gln (NBS1 E185Q, NBS1 8360G>C, rs1805794) polymorphism has been indicated to be involved in the development of cancer, but results of previous individual studies on the association between NBS1 Glu185Gln polymorphism and breast cancer risk remain controversial and inconclusive.
|
23381647 |
2013 |
Malignant Neoplasms
|
|
0.080 |
GeneticVariation
|
BEFREE |
However, rs1805794, D95N and P266L did not appear to have an effect on cancer risk.
|
24113799 |
2013 |
Malignant Neoplasms
|
|
0.080 |
GeneticVariation
|
BEFREE |
The NBS1 Glu185Gln (NBS1 E185Q, NBS1 8360G>C, rs1805794) polymorphism has been indicated to be involved in the development of cancer, but results of previous individual studies on the association between NBS1 Glu185Gln polymorphism and breast cancer risk remain controversial and inconclusive.
|
23381647 |
2013 |
Primary malignant neoplasm
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggests that the NBS1 E185Q variant genotypes (8360 GC/CC) might be associated with an increased risk of cancer, especially in Caucasians.
|
19393077 |
2009 |
Malignant Neoplasms
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggests that the NBS1 E185Q variant genotypes (8360 GC/CC) might be associated with an increased risk of cancer, especially in Caucasians.
|
19393077 |
2009 |
Malignant neoplasm of lung
|
|
0.060 |
GeneticVariation
|
BEFREE |
Using the multifactor dimensionality reduction method, we found a model of gene-gene interactions associated with the risk of lung cancer: NBS1 (rs1805794)-XRCC1 (rs25487)-hOGG1 (rs1052133)-XPG (rs17655).
|
31584889 |
2019 |
Carcinoma of lung
|
|
0.060 |
GeneticVariation
|
BEFREE |
Using the multifactor dimensionality reduction method, we found a model of gene-gene interactions associated with the risk of lung cancer: NBS1 (rs1805794)-XRCC1 (rs25487)-hOGG1 (rs1052133)-XPG (rs17655).
|
31584889 |
2019 |
Primary malignant neoplasm of lung
|
|
0.060 |
GeneticVariation
|
BEFREE |
Using the multifactor dimensionality reduction method, we found a model of gene-gene interactions associated with the risk of lung cancer: NBS1 (rs1805794)-XRCC1 (rs25487)-hOGG1 (rs1052133)-XPG (rs17655).
|
31584889 |
2019 |
Carcinoma of lung
|
|
0.060 |
GeneticVariation
|
BEFREE |
The CC genotype of NBS1 Glu185Gln may increase lung cancer risk only for males and smokers and may serve as a practical marker for early detective and predictive purposes of lung cancer.
|
28476809 |
2017 |
Primary malignant neoplasm of lung
|
|
0.060 |
GeneticVariation
|
BEFREE |
The CC genotype of NBS1 Glu185Gln may increase lung cancer risk only for males and smokers and may serve as a practical marker for early detective and predictive purposes of lung cancer.
|
28476809 |
2017 |
Malignant neoplasm of lung
|
|
0.060 |
GeneticVariation
|
BEFREE |
The CC genotype of NBS1 Glu185Gln may increase lung cancer risk only for males and smokers and may serve as a practical marker for early detective and predictive purposes of lung cancer.
|
28476809 |
2017 |
Malignant neoplasm of lung
|
|
0.060 |
GeneticVariation
|
BEFREE |
The meta-analysis further confirmed the association between the variant rs1805794G>C and lung cancer</span> risk, that compared with the GG genotype, the carriers of C genotypes had a 1.30-fold risk of cancer (95% CI=1.14-1.49, P=8.49×10(-5)).
|
25771871 |
2014 |
Carcinoma of lung
|
|
0.060 |
GeneticVariation
|
BEFREE |
The functional polymorphism of NBS1 p.Glu185Gln is associated with an increased risk of lung cancer in Chinese populations: case-control and a meta-analysis.
|
25771871 |
2014 |
Carcinoma of lung
|
|
0.060 |
GeneticVariation
|
BEFREE |
The meta-analysis further confirmed the association between the variant rs1805794G>C and lung cancer</span> risk, that compared with the GG genotype, the carriers of C genotypes had a 1.30-fold risk of cancer (95% CI=1.14-1.49, P=8.49×10(-5)).
|
25771871 |
2014 |