rs1867277, PTCSC2;FOXE1

N. diseases: 10
Disease: Thyroid Neoplasm ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Thyroid Neoplasm
CUI: C0040136
Disease: Thyroid Neoplasm
0.050 GeneticVariation BEFREE The genetic susceptibility of thyroid cancer seems likely to be associated with the risk allele at rs944289 in the TITF1 gene and at rs1867277, rs965513, rs1443434, and rs907580 in the TITF2 gene. 26206751 2015
Thyroid Neoplasm
CUI: C0040136
Disease: Thyroid Neoplasm
0.050 GeneticVariation BEFREE In a multicenter retrospective case-control study, five thyroid cancer-related SNPs-rs966513 (9q22.33, FOXE1), rs944289 (14q13.3, PTCSC3), rs2439302 (8p12, NRG1), rs1867277 (9q22.23, FOXE1), and rs6983267 (8q24, POU5F1B)-were genotyped in 959 cases of histologically verified FA, 535 papillary thyroid carcinomas (PTC), and 2766 population controls. 25562676 2015
Thyroid Neoplasm
CUI: C0040136
Disease: Thyroid Neoplasm
0.050 GeneticVariation BEFREE After that, a number of studies reported that the rs965513, rs1867277, and rs71369530 polymorphism in FOXE1 has been implicated in TC risk. 24489898 2014
Thyroid Neoplasm
CUI: C0040136
Disease: Thyroid Neoplasm
0.050 GeneticVariation BEFREE Five single nucleotide polymorphisms (SNPs) associated with thyroid cancer (TC) risk have been reported: rs2910164 (5q24); rs6983267 (8q24); rs965513 and rs1867277 (9q22); and rs944289 (14q13). 22282540 2012
Thyroid Neoplasm
CUI: C0040136
Disease: Thyroid Neoplasm
0.050 GeneticVariation BEFREE We propose a FOXE1 regulation model dependent on the rs1867277 genotype, indicating that this SNP is a causal variant in thyroid cancer susceptibility. 19730683 2009