|
Thyroid carcinoma
|
|
0.750 |
GeneticVariation
|
BEFREE |
In a multicenter retrospective case-control study, five thyroid cancer-related SNPs-rs966513 (9q22.33, FOXE1), rs944289 (14q13.3, PTCSC3), rs2439302 (8p12, NRG1), rs1867277 (9q22.23, FOXE1), and rs6983267 (8q24, POU5F1B)-were genotyped in 959 cases of histologically verified FA, 535 papillary thyroid carcinomas (PTC), and 2766 population controls.
|
25562676 |
2015 |
|
Thyroid carcinoma
|
|
0.750 |
GeneticVariation
|
BEFREE |
The genetic susceptibility of thyroid cancer seems likely to be associated with the risk allele at rs944289 in the TITF1 gene and at rs1867277, rs965513, rs1443434, and rs907580 in the TITF2 gene.
|
26206751 |
2015 |
|
Thyroid carcinoma
|
|
0.750 |
GeneticVariation
|
BEFREE |
After that, a number of studies reported that the rs965513, rs1867277, and rs71369530 polymorphism in FOXE1 has been implicated in TC risk.
|
24489898 |
2014 |
|
Thyroid carcinoma
|
|
0.750 |
GeneticVariation
|
BEFREE |
Five single nucleotide polymorphisms (SNPs) associated with thyroid cancer (TC) risk have been reported: rs2910164 (5q24); rs6983267 (8q24); rs965513 and rs1867277 (9q22); and rs944289 (14q13).
|
22282540 |
2012 |
|
Thyroid carcinoma
|
|
0.750 |
GeneticVariation
|
GWASDB |
The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl.
|
20350937 |
2010 |
|
Thyroid carcinoma
|
|
0.750 |
GeneticVariation
|
BEFREE |
We propose a FOXE1 regulation model dependent on the rs1867277 genotype, indicating that this SNP is a causal variant in thyroid cancer susceptibility.
|
19730683 |
2009 |
|
Papillary thyroid carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
There were significant associations of all SNPs with PTC (rs965513 odds ratio [OR] = 1.72, p = 8 × 10-7; rs1867277 OR = 1.59, p = 1 × 10-6; rs1443434 OR = 1.53, p = 1 × 10-5; rs944289 OR = 1.52, p = 4 × 10-5).
|
28660995 |
2017 |
|
Papillary thyroid carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
The functional variants rs965513 and rs1867277 independently contribute to genetic predisposition to PTC, while a contributing role of the FOXE1 poly-Ala polymorphism could not be confirmed.
|
27824288 |
2017 |
|
Papillary thyroid carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
The presence of allele A in rs186</span>7277 was more significantly associated with several histopathological parameters in classic variant in papillary thyroid carcinoma cases such as, the presence of the A allele was found relationship with lymph node invasion risk by 2.0 fold, capsular invasion risk by 2.39 fold , and pT3 with pT4 pathological stage risk by 3.57 fold.
|
26722557 |
2015 |
|
Papillary thyroid carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
In PTC, significant associations were confirmed for rs965513 (p=4.21E-04; OR 1.587 [CI 1.235-2.000]) and rs944289 (p=0.003; OR 1.234 [CI 1.075-1.408]), newly found for rs2439302 (p=0.003; OR 1.266 [CI 1.087-1.493]) and rs1867277 (p=1.17E-04; OR 1.492 [CI 1.235-1.818]), and was not replicated for rs6983267 (p=0.082; OR 1.136 [CI 0.980-1.316]) in this series.
|
25562676 |
2015 |
|
Papillary thyroid carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Significant association with PTC was found for rs1801516 (D1853N) in ATM (odds ratio (OR) = 0.34, 95% confidence interval (CI) 0.16, 0.73) and rs1867277 in the promoter region of FOXE1 (OR = 1.55, 95% CI 1.03, 2.34).
|
24105688 |
2014 |
|
Papillary thyroid carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Nuclear FOXE1 expression in tumor cells in the vicinity of the PTC border is associated with the presence of a risk allele of rs1867277 (c.-238G>A) in the 5' untranslated region of the FOXE1 gene, as well as with pathological characteristics of PTC, suggesting possible FOXE1 involvement in the facilitation of tumor development beginning at an early stage.
|
23327367 |
2013 |
|
Papillary thyroid carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
We confirmed the strong association of rs1867277 with PTC (overall P = 1 × 10(-7), odds ratio 1.84, confidence interval 1.31-2.57). rs1867277 was in tight linkage disequilibrium with the FOXE1 polyalanine repeat region (r(2) = 0.95).
|
22736773 |
2012 |
|
Papillary thyroid carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
The effect of Ala length and rs1867277 alleles on FOXE1 expression was investigated by mRNA relative real time quantification on 8 papillary thyroid carcinoma (PTC) and 10 Graves' disease (GD) genotyped thyroid biopsies.
|
21896990 |
2011 |
|
Malignant neoplasm of thyroid
|
|
0.050 |
GeneticVariation
|
BEFREE |
The genetic susceptibility of thyroid cancer seems likely to be associated with the risk allele at rs944289 in the TITF1 gene and at rs1867277, rs965513, rs1443434, and rs907580 in the TITF2 gene.
|
26206751 |
2015 |
|
Thyroid Neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
The genetic susceptibility of thyroid cancer seems likely to be associated with the risk allele at rs944289 in the TITF1 gene and at rs1867277, rs965513, rs1443434, and rs907580 in the TITF2 gene.
|
26206751 |
2015 |
|
Thyroid Neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
In a multicenter retrospective case-control study, five thyroid cancer-related SNPs-rs966513 (9q22.33, FOXE1), rs944289 (14q13.3, PTCSC3), rs2439302 (8p12, NRG1), rs1867277 (9q22.23, FOXE1), and rs6983267 (8q24, POU5F1B)-were genotyped in 959 cases of histologically verified FA, 535 papillary thyroid carcinomas (PTC), and 2766 population controls.
|
25562676 |
2015 |
|
Malignant neoplasm of thyroid
|
|
0.050 |
GeneticVariation
|
BEFREE |
In a multicenter retrospective case-control study, five thyroid cancer-related SNPs-rs966513 (9q22.33, FOXE1), rs944289 (14q13.3, PTCSC3), rs2439302 (8p12, NRG1), rs1867277 (9q22.23, FOXE1), and rs6983267 (8q24, POU5F1B)-were genotyped in 959 cases of histologically verified FA, 535 papillary thyroid carcinomas (PTC), and 2766 population controls.
|
25562676 |
2015 |
|
Malignant neoplasm of thyroid
|
|
0.050 |
GeneticVariation
|
BEFREE |
After that, a number of studies reported that the rs965513, rs1867277, and rs71369530 polymorphism in FOXE1 has been implicated in TC risk.
|
24489898 |
2014 |
|
Thyroid Neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
After that, a number of studies reported that the rs965513, rs1867277, and rs71369530 polymorphism in FOXE1 has been implicated in TC risk.
|
24489898 |
2014 |
|
Thyroid Neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
Five single nucleotide polymorphisms (SNPs) associated with thyroid cancer (TC) risk have been reported: rs2910164 (5q24); rs6983267 (8q24); rs965513 and rs1867277 (9q22); and rs944289 (14q13).
|
22282540 |
2012 |
|
Malignant neoplasm of thyroid
|
|
0.050 |
GeneticVariation
|
BEFREE |
Five single nucleotide polymorphisms (SNPs) associated with thyroid cancer (TC) risk have been reported: rs2910164 (5q24); rs6983267 (8q24); rs965513 and rs1867277 (9q22); and rs944289 (14q13).
|
22282540 |
2012 |
|
Malignant neoplasm of thyroid
|
|
0.050 |
GeneticVariation
|
BEFREE |
We propose a FOXE1 regulation model dependent on the rs1867277 genotype, indicating that this SNP is a causal variant in thyroid cancer susceptibility.
|
19730683 |
2009 |
|
Thyroid Neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
We propose a FOXE1 regulation model dependent on the rs1867277 genotype, indicating that this SNP is a causal variant in thyroid cancer susceptibility.
|
19730683 |
2009 |
|
Differentiated Thyroid Gland Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
This meta-analysis revealed that common variations of FOXE1 (rs965513, rs944289 and rs1867277) were risk factors associated with increased DTC susceptibility.
|
29788924 |
2018 |