|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (SNP) rs1893217 within the gene locus encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) results in a dysfunctional PTPN2 protein is associated with Crohn's disease (CD) and exists in perfect linkage disequilibrium with the CD- and ulcerative colitis (UC)-associated PTPN2 SNP rs2542151.
|
26928573 |
2016 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
Moreover, a significant increase in CD risk for all carriers of the minor allele of rs1893217 (OR = 1.45, 95 % CI, 1.23-1.70, I (2) = 0 %) and rs7234029 (OR = 1.36, 95 % CI, 1.16-1.59, I (2) = 0 %) were found.
|
24127071 |
2014 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
In stage 1, we observed associations between 5 intronic SNPs and CD including rs1893217 (P = 2 × 10⁻⁴), the SNP that is in perfect linkage disequilibrium with the lead genome-wide association studies SNP rs2542151.
|
23518806 |
2013 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
We identified a novel association between the genetic variant, rs1893217, located in intron 7 of the PTPN2 gene and CD.
|
22021207 |
2012 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
GWASDB |
A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease.
|
21298027 |
2011 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
21102463 |
2010 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
GWASDB |
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
21102463 |
2010 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
Allelic association analysis (two-tailed) showed that three of the five targeted SNPs were significantly associated with overall susceptibility for CD (ZNF365, r10995271, P = 0.001; PTPN2, rs1893217, P = 0.005; STAT3, rs744166, P = 0.01).
|
20222910 |
2010 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
BEFREE |
Our results suggest that rs1893217 may increase the risk of early-onset T1D and affect humoral immunity, while rs478582 may affect Treg subsets.
|
31030572 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
|
25751624 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
BEFREE |
The rs1893217 (T/C) polymorphism in PTPN2 gene is not associated with type 1 diabetes mellitus in subjects from Southern Brazil.
|
24936733 |
2014 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
BEFREE |
In children with the PTPN2 rs1893217 AA genotype, the VDR rs1544410 AA/AG genotype was associated with a decreased risk of T1D (HR: 0.24, 95% CI: 0.11-0.53, p=0.0004), while in children with the PTPN2 rs1893217 GG/GA genotype, the VDR rs1544410 AA/AG genotype was not associated with T1D (HR: 1.32, 95% CI: 0.43-4.06, p=0.62).
|
22960018 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
GWASDB |
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
|
21980299 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
GWASDB |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
|
Autoimmune Diseases
|
|
0.810 |
GeneticVariation
|
BEFREE |
Genome-wide association studies have linked single-nucleotide polymorphisms in the phosphatases <i>PTPN22</i> (rs2476601) and <i>PTPN2</i> (rs1893217) to increased risk for multiple autoimmune diseases.
|
31722988 |
2019 |
|
Autoimmune Diseases
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Inflammatory Bowel Diseases
|
|
0.810 |
GeneticVariation
|
BEFREE |
We investigated associations of PTPN2 SNP rs1893217 and clinical characteristics of inflammatory bowel disease (IBD) patients.
|
26928573 |
2016 |
|
Inflammatory Bowel Diseases
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Inflammatory Bowel Diseases
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Inflammatory Bowel Diseases
|
|
0.810 |
GeneticVariation
|
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Autoimmune Diseases
|
|
0.810 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
|
21383967 |
2011 |
|
Autoimmune Diseases
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
|
21383967 |
2011 |