Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The IFIH1 rs1990760 polymorphism seems to be associated with the seasonal manifestation of T1DM.
|
28929635 |
2018 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
In summary, our study uncovers an influence of rs1990760 on the canonical effector function of MDA5 in response to an acute infection of primary human parenchymal cells with a clinically relevant virus linked to human T1D.
|
28000722 |
2016 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The risk alleles G of rs3747517, rs2111485, rs13422767 and A of rs1990760 were observed more frequently in T1D group with P values and allelic odds ratio OR (95%CI) < 0.0001, 1.742 (1.428-2.126); 0.001, 1.336 (1.125-1.588); < 0.0001, 1.799 (1.416-2.285); 0.0005, 1.359 (1.144-1.616), respectively.
|
25515714 |
2015 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Additionally, we conducted a meta-analysis with the rs7574865 SNP in STAT4 (1392 T1D patients and 1629 controls) and the rs1990760 SNP in IFIH1 (25092 T1D patients and 28544 controls) to examine their association with T1D.
|
26782418 |
2015 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Functional characterization of the Thr946Ala SNP at the type 1 diabetes IFIH1 locus.
|
24117221 |
2014 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrates that the IFIH1 rs1990760 T-allele confers susceptibility to T1D, SLE, MS and RA and suggests that the IFIH1 rs1990760 polymorphism might have no effect on GD and AAD.
|
23734776 |
2013 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Interestingly, the rs1990760 A allele seems to be associated with protection for AH in T1DM patients.
|
24386202 |
2013 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, IFIH1 rs3747517, but not rs1990760 polymorphism, plays an important role in type 1 diabetes risk in Chinese Han population.
|
22053898 |
2012 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Enterovirus RNA in peripheral blood may be associated with the variants of rs1990760, a common type 1 diabetes associated polymorphism in IFIH1.
|
23144876 |
2012 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASDB |
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
|
21980299 |
2011 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Summarising the data published so far, a clear association between the Ala946Thr polymorphism and type 1 diabetes was detected, with an apparent difference in the contribution to disease susceptibility in different populations of European ancestry.
|
19841890 |
2010 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
In addition to the known association of HLA with IgAD, we identified association with a nonsynonymous variant in IFIH1 (rs1990760G>A, P = 7.3 x 10(-10)) which was previously associated with type 1 diabetes and systemic lupus erythematosus.
|
20694011 |
2010 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Moreover, the association of the Thr946Ala SNP with T1D is not due to modulation of IFIH1 expression in organs involved in the disease, pointing to the IFIH1 nsSNP as the causal variant.
|
20644636 |
2010 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Among the 10 SNPs genotyped for the 2q region, four SNPs located within the IFIH1 gene or at the 5' region of IFIH1 showed significant association with T1D in the Georgia population [odds ratio (OR) = 1.7-1.9] with the best P-value found at SNP rs1990760 (P = 8 x 10(-8) and OR = 1.9).
|
18927125 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent studies showed that a genetic variation within the interferon induced helicase domain 1 (IFIH1) locus (rs1990760 polymorphism) is an additional risk factor in type 1 diabetes and Graves' disease (GD).
|
19961590 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, the A946T mutation of MDA5, which has been implicated in type I diabetes by previous genetic analyses, affected neither dsRNA binding nor IFN gene activation.
|
19324880 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Evidence for association with T1D was observed for the IFIH1 SNP, rs1990760 (P=7.0 x 10(-4)), with RR=0.88 (0.82-0.95) and the CTLA4 SNP rs1427676 (P=0.0005), with RR=1.14 (1.06-1.23).
|
19956106 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
|
17554260 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
A recent large-scale analysis of nonsynonymous coding polymorphisms showed strong evidence that an alanine to threonine amino acid change at codon 946 of the interferon-induced helicase (IFIH1) gene (SNP ID rs1990760) was associated with type 1 diabetes.
|
17535987 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of the present study was to investigate the role of the interferon induced with helicase domain 1 (IFIH1) A946T (rs1990760 A>G) variant in rheumatoid arthritis (RA), as this was recently associated with susceptibility to type 1 diabetes.
|
17442111 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASDB |
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
|
17554260 |
2007 |