|
Lupus Erythematosus, Systemic
|
|
0.780 |
GeneticVariation
|
BEFREE |
In conclusion, IFIH1 polymorphisms (rs1990760 and rs3747517) were associated with SLE susceptibility and rs1990760 risk T allele related with IL-18 and granzyme B serum levels in SLE patients.
|
29930297 |
2018 |
|
Lupus Erythematosus, Systemic
|
|
0.780 |
GeneticVariation
|
BEFREE |
We concluded that IFIH1 rs1990760_T and TYK2 rs2304256_C alleles were significantly associated with SLE, and IL-10 rs1800896 GG homozygote might have an enhancement effect on SLE risk.
|
30171347 |
2018 |
|
Lupus Erythematosus, Systemic
|
|
0.780 |
GeneticVariation
|
BEFREE |
However, meta-analysis of peer-reviewed articles from 2008 to 2015 and data from this study indicated an association between rs1990760 and SLE onset (P < 0.05).
|
27813554 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.780 |
GeneticVariation
|
GWASCAT |
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.
|
26502338 |
2015 |
|
Lupus Erythematosus, Systemic
|
|
0.780 |
GeneticVariation
|
BEFREE |
Our study supports previous findings of an association between the rs1990760 polymorphism of IFIH1 and SLE and indicates that this SNP may also be associated with malar rash in SLE patients although this finding needs confirmation.
|
24719229 |
2014 |
|
Lupus Erythematosus, Systemic
|
|
0.780 |
GeneticVariation
|
BEFREE |
In conclusion, our study represents the first report demonstrating an association of the IFIH1 rs1990760</span> polymorphism with SLE susceptibility in a Chinese population.
|
23108955 |
2013 |
|
Lupus Erythematosus, Systemic
|
|
0.780 |
GeneticVariation
|
BEFREE |
We studied the impact of the autoimmune-disease-associated IFIH1 rs1990760 (A946T) single nucleotide polymorphism upon IFN-α signaling in SLE patients in vivo.
|
21705624 |
2011 |
|
Lupus Erythematosus, Systemic
|
|
0.780 |
GeneticVariation
|
BEFREE |
The aim of the present study was to evaluate whether the interferon-induced helicase (IFIH1) Ala946Thr (rs1990760 A>G) polymorphism is associated with susceptibility to systemic lupus erythematosus (SLE) and dermatomyositis (DM) or polymyositis (PM) in the Japanese population.
|
20467774 |
2010 |
|
Lupus Erythematosus, Systemic
|
|
0.780 |
GeneticVariation
|
BEFREE |
In addition to the known association of HLA with IgAD, we identified association with a nonsynonymous variant in IFIH1 (rs1990760G>A, P = 7.3 x 10(-10)) which was previously associated with type 1 diabetes and systemic lupus erythematosus.
|
20694011 |
2010 |
|
Lupus Erythematosus, Systemic
|
|
0.780 |
GeneticVariation
|
GWASCAT |
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
|
19838195 |
2009 |