rs199649035, JAK3

N. diseases: 2
Disease: Precursor T-Cell Lymphoblastic Leukemia-Lymphoma ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
CUI: C1961099
Disease: Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.010 GeneticVariation BEFREE U2AF1 p.R35L was shown to induce aberrant splicing of downstream target genes, and shRNA knockdown of MED12 and USP9X was shown to confer resistance to apoptosis following T-ALL relevant chemotherapy drug treatment in Jurkat leukemia cells. 27602765 2016