|
Rheumatoid Arthritis
|
|
0.790 |
GeneticVariation
|
BEFREE |
The SNP rs2004640 was significantly associated with SLE, MS, and SSc, but not with JIA [odds ratio (OR)=1.06, 95% confidence interval (CI)=0.90-1.24, P=0.48] or RA (OR=1.03, 95%CI=0.95-1.11, P=0.44).
|
25036352 |
2014 |
|
Rheumatoid Arthritis
|
|
0.790 |
GeneticVariation
|
BEFREE |
Interestingly, a protective effect of both IRF5 rs2004640 GG and IRF5 rs10954213 GG genotypes against the risk for CV events after adjusting the results for sex, age at RA diagnosis and traditional CV disease risk factors was observed (hazard ratio (HR) = 0.6, 95% confidence interval (CI) = 0.38 to 0.92, P = 0.02; and HR = 0.58, 95% CI = 0.36 to 0.95, P = 0.03, respectively).
|
25011482 |
2014 |
|
Rheumatoid Arthritis
|
|
0.790 |
GeneticVariation
|
BEFREE |
The results suggest that the IRF5 rs2004640 polymorphism is associated with rheumatoid arthritis especially when the dominant genetic model is applied.
|
23801380 |
2013 |
|
Rheumatoid Arthritis
|
|
0.790 |
GeneticVariation
|
BEFREE |
This meta-analysis confirms that the IRF5 rs2004640, rs729302 and rs752637 polymorphisms are associated with RA susceptibility in different ethnic groups, especially in Europeans and Asians, but further study of this association is required in other ethnic groups.
|
23073787 |
2013 |
|
Rheumatoid Arthritis
|
|
0.790 |
GeneticVariation
|
BEFREE |
Odds ratios (OR) were employed to evaluate the risk of RA according to the 4 single-nucleotide polymorphisms (SNP) in IRF5 (rs729302, rs2004640, rs752637, and rs2280714) and data were analyzed in respect to association between alleles.
|
19228650 |
2009 |
|
Rheumatoid Arthritis
|
|
0.790 |
GeneticVariation
|
BEFREE |
Our findings together with those from previous studies, in a total of 4,620 RA patients and 3,741 controls, showed a significant association of the rs2004640 IRF5 SNP in RA patients as a whole (odds ratio [OR] 0.88, 95% confidence interval [95% CI] 0.83-0.94; P = 6.5 x 10(-5) versus controls).
|
18438842 |
2008 |
|
Rheumatoid Arthritis
|
|
0.790 |
GeneticVariation
|
BEFREE |
A combined analysis including all 3 independent cohorts from the previous study revealed an association of the rs2004640 with RA (pooled OR 1.21, 95% CI 1.07-1.38, pooled p = 0.0031 in dominant model).
|
18843785 |
2008 |
|
Rheumatoid Arthritis
|
|
0.790 |
GeneticVariation
|
BEFREE |
Our results indicate that the TT genotype of the IRF5 (rs2004640) dimorphism is associated with RA in a Tunisian population.
|
18752149 |
2008 |
|
Rheumatoid Arthritis
|
|
0.790 |
GeneticVariation
|
BEFREE |
Our results exclude the IRF5 rs2004640-T allele as a major genetic factor for RA in this French Caucasian population.
|
17158136 |
2007 |
|
Rheumatoid Arthritis
|
|
0.790 |
CausalMutation
|
CLINVAR |
|
|
|