Rheumatoid Arthritis
|
|
0.790 |
GeneticVariation
|
BEFREE |
The SNP rs2004640 was significantly associated with SLE, MS, and SSc, but not with JIA [odds ratio (OR)=1.06, 95% confidence interval (CI)=0.90-1.24, P=0.48] or RA (OR=1.03, 95%CI=0.95-1.11, P=0.44).
|
25036352 |
2014 |
Rheumatoid Arthritis
|
|
0.790 |
GeneticVariation
|
BEFREE |
Interestingly, a protective effect of both IRF5 rs2004640 GG and IRF5 rs10954213 GG genotypes against the risk for CV events after adjusting the results for sex, age at RA diagnosis and traditional CV disease risk factors was observed (hazard ratio (HR) = 0.6, 95% confidence interval (CI) = 0.38 to 0.92, P = 0.02; and HR = 0.58, 95% CI = 0.36 to 0.95, P = 0.03, respectively).
|
25011482 |
2014 |
Rheumatoid Arthritis
|
|
0.790 |
GeneticVariation
|
BEFREE |
The results suggest that the IRF5 rs2004640 polymorphism is associated with rheumatoid arthritis especially when the dominant genetic model is applied.
|
23801380 |
2013 |
Rheumatoid Arthritis
|
|
0.790 |
GeneticVariation
|
BEFREE |
This meta-analysis confirms that the IRF5 rs2004640, rs729302 and rs752637 polymorphisms are associated with RA susceptibility in different ethnic groups, especially in Europeans and Asians, but further study of this association is required in other ethnic groups.
|
23073787 |
2013 |
Rheumatoid Arthritis
|
|
0.790 |
GeneticVariation
|
BEFREE |
Odds ratios (OR) were employed to evaluate the risk of RA according to the 4 single-nucleotide polymorphisms (SNP) in IRF5 (rs729302, rs2004640, rs752637, and rs2280714) and data were analyzed in respect to association between alleles.
|
19228650 |
2009 |
Rheumatoid Arthritis
|
|
0.790 |
GeneticVariation
|
BEFREE |
Our findings together with those from previous studies, in a total of 4,620 RA patients and 3,741 controls, showed a significant association of the rs2004640 IRF5 SNP in RA patients as a whole (odds ratio [OR] 0.88, 95% confidence interval [95% CI] 0.83-0.94; P = 6.5 x 10(-5) versus controls).
|
18438842 |
2008 |
Rheumatoid Arthritis
|
|
0.790 |
GeneticVariation
|
BEFREE |
A combined analysis including all 3 independent cohorts from the previous study revealed an association of the rs2004640 with RA (pooled OR 1.21, 95% CI 1.07-1.38, pooled p = 0.0031 in dominant model).
|
18843785 |
2008 |
Rheumatoid Arthritis
|
|
0.790 |
GeneticVariation
|
BEFREE |
Our results indicate that the TT genotype of the IRF5 (rs2004640) dimorphism is associated with RA in a Tunisian population.
|
18752149 |
2008 |
Rheumatoid Arthritis
|
|
0.790 |
GeneticVariation
|
BEFREE |
Our results exclude the IRF5 rs2004640-T allele as a major genetic factor for RA in this French Caucasian population.
|
17158136 |
2007 |
Rheumatoid Arthritis
|
|
0.790 |
CausalMutation
|
CLINVAR |
|
|
|
Body Height
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
SYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO, 10 (finding)
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current study suggested that individuals carrying rs2004640 T allele correlated with a high risk of SLE, and the IRF5 rs2004640 polymorphism was associated with SLE susceptibility.
|
31347288 |
2019 |
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis confirms that the IRF5 rs2004640 polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.
|
31018759 |
2019 |
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although we could not demonstrate susceptibility toward lupus in the presence of IRF5 rs2004640 (G/T) polymorphism, further exploration of the genetic variability of IRF5 may help uncover its pathogenic role in Indian SLE patients.
|
30168487 |
2018 |
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
The presence of the rs20</span>04640 T allele increases the risk of nephritis development in Egyptian children with SLE.
|
28059021 |
2017 |
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
Nevertheless, two haplotypes based on the 3 variants [exon6(in/de), rs10954213, rs2004640] of IRF5 (DAG and IAT) could define protective or susceptibility haplotype in SLE.
|
26294277 |
2015 |
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
The novelty of this study is the association of the rs2004640 T-allele with increased anti-dsDNA antibody production and SLE in a younger age group.
|
24697591 |
2015 |
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
The IRF5 haplotype (rs729302 A, rs2004640 T, and rs2280714 T), which was reported as conferring an increased risk of SLE, was significantly associated with MAS susceptibility in patients with systemic JIA (OR 4.61; 95% CI 1.73, 12.3; p < 0.001).
|
21239750 |
2011 |
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a subgroup analysis by ethnicity, significantly increased SLE risk was associated with IRF5 rs2004640 T allele in populations of European, Asian and Latin American origin, and the rs10954213 A allele is significantly associated with SLE in European origin but not in Asian origin.
|
21834935 |
2011 |
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis confirms that the IRF5 rs2004640 polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.
|
19043711 |
2009 |
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
A case-control association study was performed for rs2004640 as well as for rs10954213 and rs2280714, all of which were previously reported to be associated with SLE, in 281 SSc patients and 477 healthy controls.
|
19479858 |
2009 |
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
The CGGGG indel explains the association signal from multiple SNPs in the IRF5 gene, including rs2004640, rs10954213 and rs729302 previously considered to be causal variants in SLE.
|
18063667 |
2008 |
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results in an independent case-control sample confirm the robust association of the IRF5/rs2004640 T allele with SLE risk, and further support the relevance of the type I interferon system in the pathogenesis of SLE and autoimmunity.
|
17166181 |
2007 |
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
Haplotypes carrying the T alleles of rs2004640 and rs2280714 and the A allele of rs10954213 are over-transmitted in SLE families.
|
17189288 |
2007 |