|
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 1(finding)
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
In summary, we concluded that the VEGF gene polymorphisms rs699947, rs2010963, and rs3025039 are correlated with an elevated CAD risk.
|
29973139 |
2018 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Vascular endothelial growth factor rs20</span>10963 polymorphism may be associated with the presence of CAD and its long-term survival, but not with its severity.
|
27704620 |
2017 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our results indicated that ACE(rs4646994)-D allele alone and in the presence of VEGF(rs2010963)-G allele can be an important independent risk factor for susceptibility of CAD in T2DM patients even after correcting for conventional risk factors in a population of Iran.
|
24505095 |
2015 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
The possible association of rs699947 and rs2010963 with CAD risks warrant confirmation in independent case-control studies and may be informative for future investigations on the pathogenesis of CAD.
|
23545315 |
2013 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Logistic regression analyses revealed that the VEGFA rs699947 C/A, VEGFA rs2010963 G/C, and VEGFA rs3025039 C/T polymorphisms were not associated with a risk of CAD.
|
23880405 |
2013 |
|
Coronary Artery Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
This study tested the association between functional VEGF +405 C>G (rs2010963), -2578C>A (rs699947) polymorphisms, and coronary collaterals in patients with coronary artery disease (CAD).
|
20621071 |
2010 |
|
Age related macular degeneration
|
|
0.050 |
GeneticVariation
|
BEFREE |
However, weak correlations between 10 SNPs (CFH rs1329428 TT genotype, CFH rs3753394 CC genotype and T allele, CFH rs1410996 AA genotype, CFH rs800292 AA genotype, CFH rs800292 A allele, VEGF rs833061 TT genotype and C allele, VEGF rs2010963 CG genotype, VEGFR2 rs1531289 TT genotype, ARMS2 rs10490924 TT genotype, KCTD10 rs238104 GC genotype, rs1531289 T allele and ARMS2 rs10490924 T allele) and AMD were shown.
|
30696427 |
2019 |
|
Age related macular degeneration
|
|
0.050 |
GeneticVariation
|
BEFREE |
The aim of the present study is to carry out a systematic review and an updated meta-analysis in order to summarize the current published studies and to evaluate the associations between four common vascular endothelial growth factor (<i>VEGF</i>) polymorphisms (rs833061, rs1413711, rs3025039, and rs2010963) and AMD risk, also stratifying for AMD subtypes and ethnicity.
|
27999450 |
2016 |
|
Age related macular degeneration
|
|
0.050 |
GeneticVariation
|
BEFREE |
No association was observed between AMD risk and the variant genotypes of VEGF-A rs2010963 and rs3025039 polymorphisms in different genetic models.
|
23761723 |
2013 |
|
Age related macular degeneration
|
|
0.050 |
GeneticVariation
|
BEFREE |
The present meta-analyses indicated that there were no significantly associations between VEGF polymorphisms (rs833061, rs1413711, rs2010963) and the risk of AMD, although the association was different for each polymorphism among different populations.
|
22307787 |
2012 |
|
Age related macular degeneration
|
|
0.050 |
GeneticVariation
|
BEFREE |
In our work, we searched for an association between the -460C> (rs833061) and -634G>C (rs2010963) polymorphisms of the VEGF gene and the occurrence of AMD and its dry and wet forms.
|
19761764 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
All polymorphisms were in Hardy-Weinberg equilibrium, and the association by genotype with T2D-related traits displayed nominal significance for rs8192678 with glucose (<i>p</i> = 0.023) and triglycerides (<i>p</i> = 0.013); rs2010963 with diastolic blood pressure (DBP) (<i>p</i> = 0.012) and cholesterol (<i>p</i> = 0.013); rs7896005 with DBP (<i>p</i> = 0.012) and insulin (<i>p</i> = 0.011); and rs659366 with cholesterol (<i>p</i> = 0.034), glucose (<i>p</i> = 0.031) and triglycerides (<i>p</i> = 0.028); and the association of rs2010963 with HDL-C (<i>p</i> = 0.0007) was significant.
|
30393491 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
To assess if the included vascular endothelial growth factor (VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus (T2DM).
|
28149790 |
2017 |
|
Diabetic Retinopathy
|
|
0.040 |
GeneticVariation
|
BEFREE |
The VEGF gene SNPs analyzed with regard to DR susceptibility were rs2010963 (G > C), rs833061 (T > C), rs699947 (C > A), rs3025039 (C > T) and rs1570360 (G > A).
|
27613596 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
Vascular Endothelial Growth Factor Gene Polymorphism (rs2010963) and Its Receptor, Kinase Insert Domain-Containing Receptor Gene Polymorphism (rs2071559), and Markers of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus.
|
26881237 |
2016 |
|
Diabetic Retinopathy
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found the frequencies of the CC, CG, and GG genotype of the rs2010963 polymorphism were 15.09%, 47.14%, and 37.74% in DR and 12.90%, 19.35%, and 67.74% in DNR, respectively (p = 0.0205).
|
27648002 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our results indicated that ACE(rs4646994)-D allele alone and in the presence of VEGF(rs2010963)-G allele can be an important independent risk factor for susceptibility of CAD in T2DM patients even after correcting for conventional risk factors in a population of Iran.
|
24505095 |
2015 |
|
Diabetic Retinopathy
|
|
0.040 |
GeneticVariation
|
BEFREE |
No evidence of association was observed between -2578 A/C (rs699947), +405C/G (rs2010963), +936C/T (rs3025039), and DR risk under stringent Bonferroni's correction.
|
24534217 |
2014 |
|
Rheumatoid Arthritis
|
|
0.040 |
GeneticVariation
|
BEFREE |
VEGFA rs699947 C/A, rs2010963 G/C, and rs3025039 C/T polymorphisms were not associated with the risk of RA.
|
23848209 |
2013 |
|
Diabetic Retinopathy
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our meta-analysis confirmed the significant association between rs699947 polymorphism and DR after exclusion of outliers, and rs2010963 polymorphism might be not associated with DR.
|
24131746 |
2013 |
|
Rheumatoid Arthritis
|
|
0.040 |
GeneticVariation
|
BEFREE |
No significant association between the VEGFA rs2010963 and the rs1570360 polymorphisms (neither isolated nor joined as allelic combinations) with clinically evident CV disease was found in this series of patients with RA.
|
21388351 |
2011 |
|
Rheumatoid Arthritis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our data suggested a trend of association between VEGF gene polymorphisms and RA, and patients who carried the haplotype GA of rs2010963 and rs833070 were more susceptible to RA.
|
21245770 |
2011 |
|
Rheumatoid Arthritis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The aim of this study was to asses the role of -1154 G-->A (rs1570360) and -634 G-->C (rs2010963) VEGF gene functional variants with rheumatoid arthritis (RA).
|
16216669 |
2005 |
|
Psoriasis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Haplotype analysis suggests that the coexistence of the polymorphisms rs1799964 (TNF-α), rs2010963 (VEGF), rs833061 (VEGF), and rs6311 (5HT2A) may be a protective factor for psoriasis.
|
31148856 |
2020 |