|
Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
The estimated allele frequencies of functional polymorphisms in(of) exon 21 (2677 G>T, Ala893Ser) and exon 26(3435 C>T, Ilel 142I1e) of the MDR] gene were 0.42 and 0.46 in the controls and 0.54 (p=0.035) and 0.60 (p=0.017) in the MSI-H tumors.
|
11980438 |
2002 |
|
Colorectal Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Functional MDR1 polymorphisms (G2677T and C3435T) and TCF4 mutations in colorectal tumors with high microsatellite instability.
|
11980438 |
2002 |
|
Parkinson Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The frequency of each individual SNPs; -41 A > G (intron -1), -145 C > G (exon 1), -129 T > C (exon 1), 1236 T > C (exon 12), 2677 G > T/A (exon 21), 3435 C > T (exon 26), and 4036 A > G (exon 28) did not differ between PD and controls.
|
15542248 |
2004 |
|
Balkan Nephropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The constitutional genotype frequencies of two SNPs (C3435T and G2677T) in the MDR1 gene in 112 healthy control subjects were investigated and compared with those of 96 patients with BEN.
|
14752243 |
2004 |
|
Ulcerative Colitis
|
|
0.080 |
GeneticVariation
|
BEFREE |
Two polymorphisms (C3435T and G2677T/A) of the multidrug resistance 1 gene have been correlated with the altered P-glycoprotein expression and function in humans, and associated with predisposition to ulcerative colitis and Crohn's disease.
|
16305727 |
2005 |
|
Crohn Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
Two polymorphisms (C3435T and G2677T/A) of the multidrug resistance 1 gene have been correlated with the altered P-glycoprotein expression and function in humans, and associated with predisposition to ulcerative colitis and Crohn's disease.
|
16305727 |
2005 |
|
Ulcerative Colitis
|
|
0.080 |
GeneticVariation
|
BEFREE |
This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls).
|
15685540 |
2005 |
|
Crohn Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls).
|
15685540 |
2005 |
|
Crohn Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
The polymorphism Ala893Ser/Thr (G2677T/A) previously showed significant association with Crohn's disease (CD) and the Ile1145Ile (C3435T) with ulcerative colitis (UC).
|
16374256 |
2006 |
|
Ulcerative Colitis
|
|
0.080 |
GeneticVariation
|
BEFREE |
The polymorphism Ala893Ser/Thr (G2677T/A) previously showed significant association with Crohn's disease (CD) and the Ile1145Ile (C3435T) with ulcerative colitis (UC).
|
16374256 |
2006 |
|
Inflammatory Bowel Diseases
|
|
0.040 |
GeneticVariation
|
BEFREE |
In this study we have undertaken a meta-analysis of the available findings obtained with two SNPs polymorphism (C3435T and G2677T/A) in IBD; a significant association of 3435T allele and 3435TT genotype has been found with UC (OR = 1.17, P = 0.003 and OR = 1.36, P = 0.017, respectively).
|
16773678 |
2006 |
|
Carcinoma, Ovarian Epithelial
|
|
0.030 |
GeneticVariation
|
BEFREE |
The mdr-1 polymorphism G2677T/A in exon 21 correlates with the paclitaxel response in ovarian cancer and may be important for the function of P-glycoprotein and resistance to paclitaxel and provide useful information for individualized therapy.
|
16467099 |
2006 |
|
Primary malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
The current results taken together suggest that, aside from other known causes of lung cancer, such as tobacco smoke, the existence of polymorphisms in the ABCB1 gene and, specifically, the presence of the G2677T mutation can be crucial in conferring susceptibility to lung cancer.
|
17120199 |
2006 |
|
Carcinoma of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
The current results taken together suggest that, aside from other known causes of lung cancer, such as tobacco smoke, the existence of polymorphisms in the ABCB1 gene and, specifically, the presence of the G2677T mutation can be crucial in conferring susceptibility to lung cancer.
|
17120199 |
2006 |
|
Malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
The current results taken together suggest that, aside from other known causes of lung cancer, such as tobacco smoke, the existence of polymorphisms in the ABCB1 gene and, specifically, the presence of the G2677T mutation can be crucial in conferring susceptibility to lung cancer.
|
17120199 |
2006 |
|
Schizophrenia
|
|
0.020 |
GeneticVariation
|
BEFREE |
The present study was therefore designed to examine whether the major polymorphisms of MDR1 gene, C3435T and G2677T/A are related to therapeutic response to neuroleptics in the treatment of schizophrenia.
|
16386826 |
2006 |
|
Small cell carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings suggest that the MDR1 2677G>T and 3435C>T polymorphisms can be used for predicting treatment response to etoposide-cisplatin chemotherapy in SCLC patients.
|
16478794 |
2006 |
|
Malignant neoplasm of ovary
|
|
0.010 |
GeneticVariation
|
BEFREE |
The mdr-1 polymorphism G2677T/A in exon 21 correlates with the paclitaxel response in ovarian cancer and may be important for the function of P-glycoprotein and resistance to paclitaxel and provide useful information for individualized therapy.
|
16467099 |
2006 |
|
Familial hypercholesterolemia - heterozygous
|
|
0.010 |
GeneticVariation
|
BEFREE |
Twenty children with HeFH (aged 4.9-15.6 years) and 12 cardiac transplant recipients (aged 4.4-18.7 years and receiving triple immunosuppressive medication) who had participated in previous pharmacokinetic and pharmacodynamic studies with pravastatin were genotyped for the -11187G > A and 521T > C SNPs in the SLCO1B1 gene and for the 2677G > T/A and 3435C > T SNPs in the ABCB1 gene.
|
16722833 |
2006 |
|
ovarian neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
The mdr-1 polymorphism G2677T/A in exon 21 correlates with the paclitaxel response in ovarian cancer and may be important for the function of P-glycoprotein and resistance to paclitaxel and provide useful information for individualized therapy.
|
16467099 |
2006 |
|
Epilepsy
|
|
0.080 |
GeneticVariation
|
BEFREE |
Further analysis using a logistic regression model revealed that only 2677G>T and 3435C>T in the ABCB1 gene and their interaction term were associated with drug-resistant epilepsy after adjustment for etiology and epilepsy classification.
|
17924830 |
2007 |
|
Ulcerative Colitis
|
|
0.080 |
GeneticVariation
|
BEFREE |
The distribution of the different genotypes of single nucleotide polymorphisms (SNP) G2677T/A and C3435T of MDR1 exons 21 and 26, respectively, was studied in 154 patients (mean age, 44 yr) who had received CsA to treat severe attacks of steroid resistant UC in 11 centers in France and Belgium.
|
17206635 |
2007 |
|
Ulcerative Colitis
|
|
0.080 |
GeneticVariation
|
BEFREE |
No significant association between G2677T/A polymorphism and any specific subphenotypes was found, nor was there any association with subphenotypic categories of UC and both single nucleotide polymorphisms.
|
17260353 |
2007 |
|
Crohn Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
To investigate the contribution of multidrug resistance 1 (MDR1) gene pharmacogenetics (G2677T/A and C3435T) to the efficacy of azathioprine in inducing remission in patients with Crohn's disease (CD).
|
17262810 |
2007 |
|
Crohn Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
No significant difference was observed for genotype frequencies for both MDR1 G2677T/A and C3435T polymorphisms on overall disease susceptibility for either CD or UC patients compared with control subjects.
|
17260353 |
2007 |