|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Here, we evaluate the impact of the four most common cyclooxygenase-2 gene polymorphisms (rs689465, rs689466, rs20417 and rs20417), in combination with obesity, on the risk of breast cancer progression in a cohort of Brazilian breast cancer patients (<i>N</i> = 1038).
|
29321183 |
2018 |
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
Here, we evaluate the impact of the four most common cyclooxygenase-2 gene polymorphisms (rs689465, rs689466, rs20417 and rs20417), in combination with obesity, on the risk of breast cancer progression in a cohort of Brazilian breast cancer patients (<i>N</i> = 1038).
|
29321183 |
2018 |
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our results indicate no strong association between three most frequent COX-2 SNPs rs689465 rs689466, rs20417 studied with breast cancer risk in the single locus analysis.
|
24789723 |
2015 |
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
COX-2-rs20417 CC genotype was significantly associated with increased risk of breast cancer when comparing to G allele [ORs were 1.231 (1.050-1.444) for CC vs. GG, P = 0.01, 1.223 (1.045-1.432) for CC vs. G carrier, P = 0.01].
|
25433948 |
2015 |
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our results indicate no strong association between three most frequent COX-2 SNPs rs689465 rs689466, rs20417 studied with breast cancer risk in the single locus analysis.
|
24789723 |
2015 |
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
COX-2-rs20417 CC genotype was significantly associated with increased risk of breast cancer when comparing to G allele [ORs were 1.231 (1.050-1.444) for CC vs. GG, P = 0.01, 1.223 (1.045-1.432) for CC vs. G carrier, P = 0.01].
|
25433948 |
2015 |
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
This meta-analysis showed that COX-2 rs20417 polymorphism was correlated with an increased risk of breast cancer in Caucasians, while rs689466 was associated with a decreased risk of breast cancer in Caucasians.
|
25214704 |
2014 |
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
This meta-analysis showed that COX-2 rs20417 polymorphism was correlated with an increased risk of breast cancer in Caucasians, while rs689466 was associated with a decreased risk of breast cancer in Caucasians.
|
25214704 |
2014 |
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
In conclusion, the present meta-analysis suggests that none of the most studied three SNPs (rs5275, rs20417, and rs5277) in the COX-2 gene is a conspicuous low-penetrant risk factor for developing breast cancer.
|
20033767 |
2010 |
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation
|
BEFREE |
In conclusion, the present meta-analysis suggests that none of the most studied three SNPs (rs5275, rs20417, and rs5277) in the COX-2 gene is a conspicuous low-penetrant risk factor for developing breast cancer.
|
20033767 |
2010 |
|
Prostate carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between the cyclooxygenase 2 (COX2) -765G>C (rs20417) polymorphism and prostate cancer (PC) risk using meta-analysis.
|
26535654 |
2015 |
|
Malignant neoplasm of prostate
|
|
0.040 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between the cyclooxygenase 2 (COX2) -765G>C (rs20417) polymorphism and prostate cancer (PC) risk using meta-analysis.
|
26535654 |
2015 |
|
Prostate carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
When all groups were pooled, we did not detect a significant association of rs20417 polymorphism with prostate cancer risk.
|
22782583 |
2012 |
|
Malignant neoplasm of prostate
|
|
0.040 |
GeneticVariation
|
BEFREE |
When all groups were pooled, we did not detect a significant association of rs20417 polymorphism with prostate cancer risk.
|
22782583 |
2012 |
|
Prostate carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
In a hospital-based case/control study, 195 subjects with PCa and 250 healthy controls were investigated for the association of COX-2 -765 G>C (rs20417) and +8473 T>C (rs5275) promoter polymorphism with PCa susceptibility using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method.
|
22023987 |
2011 |
|
Malignant neoplasm of prostate
|
|
0.040 |
GeneticVariation
|
BEFREE |
In a hospital-based case/control study, 195 subjects with PCa and 250 healthy controls were investigated for the association of COX-2 -765 G>C (rs20417) and +8473 T>C (rs5275) promoter polymorphism with PCa susceptibility using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method.
|
22023987 |
2011 |
|
Malignant neoplasm of prostate
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found no evidence that rs20417</span> alters prostate cancer</span> risk (odds</span> ratio (OR(CC & GC v GG)=1.05, 95% confidence interval (CI)=0.91-1.20).
|
19488068 |
2009 |
|
Prostate carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found no evidence that rs20417</span> alters prostate cancer</span> risk (odds</span> ratio (OR(CC & GC v GG)=1.05, 95% confidence interval (CI)=0.91-1.20).
|
19488068 |
2009 |
|
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
We investigated five variants (rs5788, rs1330344, rs3842788, rs20417, and rs689466) of two COX genes in order to explaining the association between these polymorphisms and we also investigated the association between these variants and ischemic stroke risk to determine whether gene-gene interaction between these genes increases the susceptibility of ischemic stroke or its subtypes.
|
31735164 |
2019 |
|
Liver carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the subgroup analyses stratified by ethnicity, the COX-2 -1195G/A, -765G/C, and +8473T/C were all associated with an increased HCC risk in Asian populations (rs689466 A vs. G: OR = 1.346, P = 0.001, 95% CI: 1.137-1.595, I<sup>2</sup> = 0.0%, P<sub>heterogeneity</sub> = 0.869; rs20417 CC vs. GG + GC: OR = 3.069, P = 0.013, 95% CI: 1.265-7.447; rs5275 CC vs. TT + TC: OR = 1.626, P = 0.020, 95% CI: 1.079-2.452, I<sup>2</sup> = 0.0%, P<sub>heterogeneity</sub> = 0.495).
|
29578159 |
2018 |
|
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
The high-risk interactive genotypes of rs20417, rs1371097 and rs2317676 were independently associated with primary adverse outcome of RIS, MI, and death after acute IS.
|
28344655 |
2017 |
|
Cerebrovascular accident
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the Brazilian cohort, rs20417 polymorphism was associated with both stroke (P = 5 × 10(-6)) and decreased PGE2 levels (P = 4 × 10(-5)); similarly, Chagas was associated with stroke (P = 4 × 10(-3)) and decreased PGE2 levels (P = 7 × 10(-3)).
|
25957909 |
2015 |
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
These results suggest that COX-2 rs20417 polymorphism may contribute to CAD development, especially in Asians.
|
24513487 |
2014 |
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Among patients with previous coronary artery disease (CAD), rs20417 carriers had a stronger protective effect on risk of major adverse events when compared with individuals without previous CAD (interaction P-value: 0.015).
|
24796340 |
2014 |
|
Liver carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results showed that the Cox-2 rs20417 (-765 G/C) polymorphism was not associated with HCC risk in the studied genetic contrast modes (C vs. G, GC vs. GG, and CC + GC vs. GG).
|
25400773 |
2014 |