Further stratification by IS subtypes revealed that the presence of the TT genotype of the <i>RAGE</i> rs2070600 variant confers a higher risk of the large artery atherosclerosis subtype of IS (P = 0.036).
The current meta-analysis suggests that the RAGE Gly82Ser polymorphism is associated with an increased risk of CAD and IS, especially in the Chinese population.
Our results showed a close correlation between the 82G/S polymorphism and the susceptibility to IS, suggesting the 82G/S polymorphism may be used as a genetic marker for the prediction of stroke occurrence in high risk subjects.