|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Compared with their corresponding wild-type genotypes, one coding variant, rs2305948 (Val297Ile), in the vascular endothelial growth factor receptor-2 gene was associated with increased susceptibility to intracerebral hemorrhage (additive model: OR, 2.06; 95% CI, 1.64 to 2.59; P=7.6x10(-10); dominant model: OR, 2.20; 95% CI, 1.70 to 2.84; P=1.5x10(-9)), a promoter variant rs2071559 (-604T>C) in the gene was associated with reduced susceptibility to atherothrombotic stroke (additive model: OR, 0.82; 95% CI, 0.71 to 0.93; P=0.003; dominant model: OR, 0.78; 95% CI, 0.65 to 0.92; P=0.004) and was reversely correlated with carotid artery intima media thickness (P=2.8x10(-5)).
|
19520980 |
2009 |
|
Age related macular degeneration
|
|
0.020 |
GeneticVariation
|
BEFREE |
Two polymorphisms (rs833069 in intron 2 of the VEGF-A gene, rs2071559 in the promoter of the KDR gene) were significantly associated with risk of AMD.
|
20471686 |
2010 |
|
Glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three SNPs, rs2071559, rs7667298 and rs2305948, showed a statistically significant increased association with the risk of glioma (P = 0.006, 0.005, and 0.012, respectively).
|
22274884 |
2012 |
|
Age related macular degeneration
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our study shows that VEGFA rs699947 and rs833061 and VEGFR2 rs2071559 polymorphisms do not modify the risk of suffering AMD in a Spanish population.
|
23971975 |
2013 |
|
Glycogen storage disease type II
|
|
0.010 |
GeneticVariation
|
BEFREE |
VEGF A (rs699947 and rs833061) and VEGFR2 (rs2071559) gene polymorphisms are not associated with AMD susceptibility in a Spanish population.
|
23971975 |
2013 |
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
A significantly higher frequency of the CC genotype of the KDR -604T>C (rs2071559) polymorphism was found in diabetic patients with MI compared to diabetic patients without CAD (27.5% vs. 21.1%, p=0.04).
|
25128838 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
The present study demonstrates that the CC genotype of the KDR -604T>C polymorphism (rs2071559) is a possible risk factor for MI in Caucasians with T2DM.
|
25128838 |
2014 |
|
Diabetic Retinopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
After adjustment for covariates, significant association of DR remained with the homozygous genotype of the minor allele for the SNPs rs699947 (odds ratio [OR] = 3.54, 95% confidence interval [CI]: 1.12-11.19), rs833061 (OR = 3.72, 95% CI: 1.17-11.85), rs13207351 (OR = 3.76, 95% CI: 1.21-11.71), and rs2146323 (OR = 2.8, 95% CI: 1.46-5.37) in the VEGF gene as well as the SNP rs2071559 (OR = 1.62, 95% CI: 1.08-2.41) in the KDR gene.
|
24623964 |
2014 |
|
Tumor thrombus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data showed that genotype AA+TA of rs1870377 and genotype CC+TC of rs2071559 were significantly associated with overall survival of HCC patients (P<0.001 and P<0.001, respectively) and remained as significant predictors for OS adjusting for high level of serum AFP (>400 μg/L), existence of portal vein tumor thrombus, and high BCLC stage (HR=0.61; 95% CI, 0.36-0.88; P=0.003 and HR=0.54; 95% CI, 0.40-0.94; P=0.002, respectively).
|
25123269 |
2014 |
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study demonstrates that the CC genotype of the KDR -604T>C polymorphism (rs2071559) is a possible risk factor for MI in Caucasians with T2DM.
|
25128838 |
2014 |
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data showed that genotype AA+TA of rs1870377 and genotype CC+TC of rs2071559 were significantly associated with overall survival of HCC patients (P<0.001 and P<0.001, respectively) and remained as significant predictors for OS adjusting for high level of serum AFP (>400 μg/L), existence of portal vein tumor thrombus, and high BCLC stage (HR=0.61; 95% CI, 0.36-0.88; P=0.003 and HR=0.54; 95% CI, 0.40-0.94; P=0.002, respectively).
|
25123269 |
2014 |
|
Tumor Cell Invasion
|
|
0.010 |
GeneticVariation
|
BEFREE |
At multivariate analysis, major vascular invasion and rs1870377 were independent factors in TTP and performance status, rs1870377, and rs2071559 were independent factors in OS.
|
25182707 |
2014 |
|
Metastatic Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
No SNP predicted axitinib outcomes.Although VEGFR2 rs2071559 predicted sorafenib efficacy in patients with mRCC, sensitivity/specificity limitations preclude its use for selecting individual patients for sorafenib treatment.
|
25816720 |
2015 |
|
Metastatic Renal Cell Cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
No SNP predicted axitinib outcomes.Although VEGFR2 rs2071559 predicted sorafenib efficacy in patients with mRCC, sensitivity/specificity limitations preclude its use for selecting individual patients for sorafenib treatment.
|
25816720 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
In the present study, we demonstrated minor effect of the rs2071559 of KDR on markers of carotid atherosclerosis in subjects with T2DM.
|
26881237 |
2016 |
|
Astrocytoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Meanwhile, stratified analysis demonstrated that mutation of rs2071559 and rs2305948 could elevate the risk of astrocytomas more significantly in the subgroup of smokers than the nonsmokers.
|
26081139 |
2016 |
|
Exudative age-related macular degeneration
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL-8 rs4073 and VEGFR-2 rs2071559 genotypes may represent important molecular determinants to modulate final outcomes in neovascular age-related macular degeneration patients.
|
26653034 |
2016 |
|
Carotid Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we demonstrated minor effect of the rs2071559 of KDR on markers of carotid atherosclerosis in subjects with T2DM.
|
26881237 |
2016 |
|
Lymphatic Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs2071559 polymorphism was shown to have an association with lymphatic metastasis in patients with NPC; however, the precise molecular mechanism should be elucidated in additional studies.
|
29344214 |
2017 |
|
Nasopharyngeal carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs2071559 polymorphism was shown to have an association with lymphatic metastasis in patients with NPC; however, the precise molecular mechanism should be elucidated in additional studies.
|
29344214 |
2017 |
|
Secondary malignant neoplasm of lymph node
|
|
0.010 |
GeneticVariation
|
BEFREE |
Regional lymph node metastasis was significantly correlated with the rs2071559 C allele and the related genotypes (OR 0.402, 95% CI 0.193-0.835, P=0.016; and OR 0.347, 95% CI 0.145-0.829, P=0.024, respectively).
|
29344214 |
2017 |
|
Varicosity
|
|
0.010 |
GeneticVariation
|
BEFREE |
Objective To study the association of polymorphisms rs699947, rs2010963, rs3025039 in the VEGFA gene region and rs1870377, rs2305949, rs2071559 in the VEGFR2 gene region with the risk of primary varicose veins in ethnic Russians.
|
27932624 |
2018 |
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Subgroup analyses by type of disease revealed similar significant findings for rs1870377, rs2071559, and rs2305948 polymorphisms in coronary artery disease (CAD) subgroup.
|
31339592 |
2019 |
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
KDR rs2071559 T and rs2305948 A alleles were associated with RA (<i>p</i> = 0.001, OR = 0.60, 95% CI = 0.45-0.81 and <i>p</i> = 0.008, OR = 1.71, CI = 1.15-2.54).
|
31405022 |
2019 |
|
Coronary Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Homozygous GG genotype and G allele of VEGFR2 rs2071559 polymorphism were associated with decreased risk of developing coronary artery stenosis.
|
30991288 |
2019 |