Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis of age-at-onset in Alzheimer's disease.
|
22005931 |
2012 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Collectively, our analysis shows TOMM40 rs2075650 polymorphism is associated with AD susceptibility in Asian, Caucasian, and mixed populations.
|
27328316 |
2016 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Similarly, our evidence suggested that allele A of TOMM40 rs2075650 polymorphism was a risk factor for AD (OR=2.87, 95% CI: 2.46-3.34, P value <0.001).
|
26795201 |
2016 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Both methods' results showed two identical significant SNPs associated with the A β-42 levels in CSF (rs2075650 at intron region TOMM40 with p-value ≥ 1 × 10-16 and rs439401 in the intergenic region of LOC100129500 and APOC1 with p-value ≥ 1 × 10-9) and highlighted APOC1 and TOMM40, which are well-known genes previously associated with AD.
|
26576771 |
2016 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.
|
24755620 |
2014 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
|
20885792 |
2010 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our prevalent case study comparing prevalent AD cases (n = 428) with participants with no cognitive impairment (n = 524) revealed a significant association of rs6656401 and rs3818361 (CR1), rs2075650 (TOMM40), rs7561528 (BIN1), and rs3865444 (CD33) with late-onset AD that were robust to adjustment with age and apolipoprotein E ε4 genotype.
|
24176626 |
2014 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, Kaplan-Meier survival analyses suggest that AD patients with TOMM40 allele rs2075650-G have an average age of disease onset of 6 years earlier compared with carriers of the A allele.
|
27023435 |
2017 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study of Alzheimer's disease with psychotic symptoms.
|
22005930 |
2012 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
|
19734902 |
2009 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.
|
21123754 |
2011 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
|
19734902 |
2009 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
|
19734903 |
2009 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Only TOMM40 rs2075650 showed association with clinical AD after adjusting for APOE-ε4 (p = 0.007), but not after multiple test correction (p>0.05).
|
23573206 |
2013 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide scan of copy number variation in late-onset Alzheimer's disease.
|
20061627 |
2010 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
|
20885792 |
2010 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We conclude that rs2075650 in TOMM40 gene may increase the risk of Alzheimer disease.
|
26572157 |
2016 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
|
21460841 |
2011 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses.
|
29107063 |
2018 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.
|
21379329 |
2011 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The SNPs rs2075650 and rs4420638 were linked to the most replications within a single reclassified phenotype or very similar reclassified phenotypes; both were associated with Alzheimer's disease (AD).
|
29942042 |
2019 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.
|
24770881 |
2014 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.
|
24770881 |
2014 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease.
|
19136949 |
2009 |