rs2106261, ZFHX3

N. diseases: 11
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). 19597492 2009
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation GWASDB Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). 19597492 2009
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation GWASCAT Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). 19597492 2009
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE Our results indicate that rs2106261 in ZFHX3 confers a significant risk of AF in a Chinese Han population. 21107608 2011
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation GWASDB Meta-analysis identifies six new susceptibility loci for atrial fibrillation. 22544366 2012
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation GWASCAT Meta-analysis identifies six new susceptibility loci for atrial fibrillation. 22544366 2012
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE Genetic polymorphisms in the chromosomal regions 4q25 (rs2200733) and 16q22 (rs2106261) associated with AF in genome-wide association studies were genotyped. 23132824 2013
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE In summary, our study investigated the role of genetic variants of ZFHX3 in AF and two SNPs (rs2106261, rs6499600) showed significant associations while rs16971436 conferred a borderline significant association with AF risk in Chinese Han populations. 24983873 2014
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE Among GWAS loci for AF, only three were replicated in the Chinese Han population, including SNP rs2106261 (G/A substitution) in ZFHX3, rs2200733 (C/T substitution) near PITX2c, and rs3807989 (A/G substitution) in CAV1. 26267381 2015
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE The SNPs at the PITX2 and ZFHX3 loci, but not the KCNN3 locus, were significantly associated with AF (PITX2/rs6843082_G: odds ratio 3.41, 95% CI 2.55 to 4.55, P=1.32×10(-16); PITX2/rs2200733_T: odds ratio 2.05, 95% CI 1.66 to 2.53, P=2.20×10(-11); ZFHX3/rs2106261_A: odds ratio 2.33, 95% CI 1.87 to 2.91, P=3.75×10(-14); KCNN3/rs13376333_T: odds ratio 1.74, 95% CI 0.93 to 3.25, P=0.085). 26272656 2015
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation GWASCAT Identification of six new genetic loci associated with atrial fibrillation in the Japanese population. 28416822 2017
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation GWASCAT Korean atrial fibrillation network genome-wide association study for early-onset atrial fibrillation identifies novel susceptibility loci. 28460022 2017
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation GWASCAT Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. 28416818 2017
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE We showed that the ZFHX3 polymorphism, rs2106261 (A allele), was a risk marker for AF and AF-related phenotypes. 28007413 2017
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE The ZFHX3 SNP rs2106261 minor allele is associated with lower AF recurrence rate after pulmonary vein isolation. 30180182 2018
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE The GRS was calculated using 5 SNPs (rs1448818, rs2200733, rs6843082, rs6838973 at chromosome 4q25 [<i>PITX2</i>] and rs2106261 at chromosome 16q22 [<i>ZFHX3</i>]), which showed modest associations with AF recurrence. 30808078 2019
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.900 GeneticVariation BEFREE Rs13376333 on chromosome 1q21 (in KCNN3), rs7193343 and rs2106261 on chromosome 16q22 (in ZFHX3) were not associated with AF recurrence in our meta-analysis. 31169720 2019