|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)).
|
19597492 |
2009 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
GWASDB |
Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)).
|
19597492 |
2009 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)).
|
19597492 |
2009 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results indicate that rs2106261 in ZFHX3 confers a significant risk of AF in a Chinese Han population.
|
21107608 |
2011 |
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, significant association was identified between rs2106261 in ZFHX3 and AF in the GeneID population for both allelic frequencies (P=0.001 after adjusting for covariates of age, gender, hypertension, coronary artery disease, and diabetes mellitus; OR=1.32), and genotypic frequencies assuming either an additive or recessive model (OR=1.29, P=0.001 and OR=1.77, P =0.00018, respectively).
|
21107608 |
2011 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, significant association was identified between rs2106261 in ZFHX3 and AF in the GeneID population for both allelic frequencies (P=0.001 after adjusting for covariates of age, gender, hypertension, coronary artery disease, and diabetes mellitus; OR=1.32), and genotypic frequencies assuming either an additive or recessive model (OR=1.29, P=0.001 and OR=1.77, P =0.00018, respectively).
|
21107608 |
2011 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
GWASDB |
Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
|
22544366 |
2012 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
|
22544366 |
2012 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms in the chromosomal regions 4q25 (rs2200733) and 16q22 (rs2106261) associated with AF in genome-wide association studies were genotyped.
|
23132824 |
2013 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
In summary, our study investigated the role of genetic variants of ZFHX3 in AF and two SNPs (rs2106261, rs6499600) showed significant associations while rs16971436 conferred a borderline significant association with AF risk in Chinese Han populations.
|
24983873 |
2014 |
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Stratification analysis indicated that the risks of AF were statistically different among subgroups of age for rs2106261, and the effect for rs16971436 was more evident in subgroups of patients with coronary artery disease.
|
24983873 |
2014 |
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Stratification analysis indicated that the risks of AF were statistically different among subgroups of age for rs2106261, and the effect for rs16971436 was more evident in subgroups of patients with coronary artery disease.
|
24983873 |
2014 |
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Stratification analysis indicated that the risks of AF were statistically different among subgroups of age for rs2106261, and the effect for rs16971436 was more evident in subgroups of patients with coronary artery disease.
|
24983873 |
2014 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Among GWAS loci for AF, only three were replicated in the Chinese Han population, including SNP rs2106261 (G/A substitution) in ZFHX3, rs2200733 (C/T substitution) near PITX2c, and rs3807989 (A/G substitution) in CAV1.
|
26267381 |
2015 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
The SNPs at the PITX2 and ZFHX3 loci, but not the KCNN3 locus, were significantly associated with AF (PITX2/rs6843082_G: odds ratio 3.41, 95% CI 2.55 to 4.55, P=1.32×10(-16); PITX2/rs2200733_T: odds ratio 2.05, 95% CI 1.66 to 2.53, P=2.20×10(-11); ZFHX3/rs2106261_A: odds ratio 2.33, 95% CI 1.87 to 2.91, P=3.75×10(-14); KCNN3/rs13376333_T: odds ratio 1.74, 95% CI 0.93 to 3.25, P=0.085).
|
26272656 |
2015 |
|
Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two of the 9 SNPs, rs2106261 (16q22) and rs6666258 (1q21), revealed interaction relationships that neared statistical significance (with point estimates in the same direction for angiotensin-converting enzyme inhibitor only and angiotensin II receptor blocker only analyses), but neither association could be replicated among 8,604 participants in Atherosclerosis Risk in Communities.
|
27179719 |
2016 |
|
Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two of the 9 SNPs, rs2106261 (16q22) and rs6666258 (1q21), revealed interaction relationships that neared statistical significance (with point estimates in the same direction for angiotensin-converting enzyme inhibitor only and angiotensin II receptor blocker only analyses), but neither association could be replicated among 8,604 participants in Atherosclerosis Risk in Communities.
|
27179719 |
2016 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
We showed that the ZFHX3 polymorphism, rs2106261 (A allele), was a risk marker for AF and AF-related phenotypes.
|
28007413 |
2017 |
|
Cerebral Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
LT was also associated with rs</span>2106261</span> (AA+AG/GG, OR=1</span>.99, 95%CI: 1.31-3.01, p=0.001).
|
28007413 |
2017 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.
|
28416818 |
2017 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Identification of six new genetic loci associated with atrial fibrillation in the Japanese population.
|
28416822 |
2017 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Korean atrial fibrillation network genome-wide association study for early-onset atrial fibrillation identifies novel susceptibility loci.
|
28460022 |
2017 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
The ZFHX3 SNP rs2106261 minor allele is associated with lower AF recurrence rate after pulmonary vein isolation.
|
30180182 |
2018 |
|
Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Further, neutrophil/lymphocyte (N/L) ratio, C-reactive protein (CRP), and interleukin-6 (IL-6) expression levels were lower in PAF patients with the ZFHX3 SNP rs2106261 minor allele (TT+TC) than in CC patients (N/L ratio: CC 2.22 ± 0.08, TT+TC 1.98 ± 0.06, p = 0.018; CRP: CC 0.103 ± 0.009 mg/dl, TT+TC 0.076 ±0.007 mg/dl, p = 0.016; IL-6: CC 60.3 ± 3.0 pg/ml, TT+TC 52.8 ± 2.3 pg/ml, p = 0.04).
|
30180182 |
2018 |
|
Paroxysmal atrial fibrillation
|
|
0.010 |
GeneticVariation
|
BEFREE |
Further, neutrophil/lymphocyte (N/L) ratio, C-reactive protein (CRP), and interleukin-6 (IL-6) expression levels were lower in PAF patients with the ZFHX3 SNP rs2106261 minor allele (TT+TC) than in CC patients (N/L ratio: CC 2.22 ± 0.08, TT+TC 1.98 ± 0.06, p = 0.018; CRP: CC 0.103 ± 0.009 mg/dl, TT+TC 0.076 ±0.007 mg/dl, p = 0.016; IL-6: CC 60.3 ± 3.0 pg/ml, TT+TC 52.8 ± 2.3 pg/ml, p = 0.04).
|
30180182 |
2018 |