Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
The GRS was calculated using 5 SNPs (rs1448818, rs2200733, rs6843082, rs6838973 at chromosome 4q25 [<i>PITX2</i>] and rs2106261 at chromosome 16q22 [<i>ZFHX3</i>]), which showed modest associations with AF recurrence.
|
30808078 |
2019 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Rs13376333 on chromosome 1q21 (in KCNN3), rs7193343 and rs2106261 on chromosome 16q22 (in ZFHX3) were not associated with AF recurrence in our meta-analysis.
|
31169720 |
2019 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
The ZFHX3 SNP rs2106261 minor allele is associated with lower AF recurrence rate after pulmonary vein isolation.
|
30180182 |
2018 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Identification of six new genetic loci associated with atrial fibrillation in the Japanese population.
|
28416822 |
2017 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Korean atrial fibrillation network genome-wide association study for early-onset atrial fibrillation identifies novel susceptibility loci.
|
28460022 |
2017 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.
|
28416818 |
2017 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
We showed that the ZFHX3 polymorphism, rs2106261 (A allele), was a risk marker for AF and AF-related phenotypes.
|
28007413 |
2017 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Among GWAS loci for AF, only three were replicated in the Chinese Han population, including SNP rs2106261 (G/A substitution) in ZFHX3, rs2200733 (C/T substitution) near PITX2c, and rs3807989 (A/G substitution) in CAV1.
|
26267381 |
2015 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
The SNPs at the PITX2 and ZFHX3 loci, but not the KCNN3 locus, were significantly associated with AF (PITX2/rs6843082_G: odds ratio 3.41, 95% CI 2.55 to 4.55, P=1.32×10(-16); PITX2/rs2200733_T: odds ratio 2.05, 95% CI 1.66 to 2.53, P=2.20×10(-11); ZFHX3/rs2106261_A: odds ratio 2.33, 95% CI 1.87 to 2.91, P=3.75×10(-14); KCNN3/rs13376333_T: odds ratio 1.74, 95% CI 0.93 to 3.25, P=0.085).
|
26272656 |
2015 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
In summary, our study investigated the role of genetic variants of ZFHX3 in AF and two SNPs (rs2106261, rs6499600) showed significant associations while rs16971436 conferred a borderline significant association with AF risk in Chinese Han populations.
|
24983873 |
2014 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms in the chromosomal regions 4q25 (rs2200733) and 16q22 (rs2106261) associated with AF in genome-wide association studies were genotyped.
|
23132824 |
2013 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
GWASDB |
Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
|
22544366 |
2012 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
|
22544366 |
2012 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results indicate that rs2106261 in ZFHX3 confers a significant risk of AF in a Chinese Han population.
|
21107608 |
2011 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)).
|
19597492 |
2009 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
GWASDB |
Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)).
|
19597492 |
2009 |
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)).
|
19597492 |
2009 |