|
Alzheimer's Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
The relationship between ABCA1 common variations (R219 K rs2230806, I883 M rs4149313 and R1587 K rs2230808) and AD has been reported in various ethnic groups; however, these studies have yielded contradictory results.
|
23111454 |
2013 |
|
Alzheimer's Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
In summary, there was no significant association detected between ABCA1 R219K, I883M and R1587K polymorphisms and risk for AD.
|
22982414 |
2012 |
|
Alzheimer's Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
Although coding SNP (rs2230808) was confirmed to have a significant association with AD, prediction of the effects of an amino acid substitution SNP rs2230808 (R1587K) on the three-dimensional structure and function of the ABCA1 protein using PolyPhen program revealed that it is unlikely to be functionally significant.
|
17510949 |
2007 |
|
Alzheimer's Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
To evaluate the relationship between ABCA1 genetic variants and Alzheimer's disease (AD), independently or in concert with the APOE epsilon4 allele, we examined three ABCA1 polymorphisms located in the coding region (R219K, I883M, and R1587K) and two ABCA1 polymorphisms in the promoter region (C-14T and C-477T) in a group of 372 Spanish AD patients and 440 controls.
|
17510946 |
2007 |
|
Alzheimer's Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
Rs2234884 and another non-synonymous SNP (R1587K) in ABCA1 (rs2234886) failed to show significant association with the risk for AD.
|
12600718 |
2003 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the initial association study, the 1587 K allele (rs2230808) was significantly more common in male patients with schizophrenia than in male controls.
|
21839797 |
2011 |
|
Dyslipidemias
|
|
0.010 |
GeneticVariation
|
BEFREE |
Dyslipidemia was observed in 10/13 (76.9%) patients with V8251 polymorphism vs. 27/37 (73%) of non-carriers, and in 16/21 (76.2%) patients with R1587K polymorphism vs. 21/29 (72.4%) in the remaining subjects.
|
19341173 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the present study was to investigate the relationship between R219K, M883I, and R1587K variants of the ATP-binding cassette transporter subfamily A number 1 (ABCA1) gene and response to rosiglitazone treatment in newly diagnosed patients with type 2 diabetes.
|
18215356 |
2008 |
|
Myocardial Ischemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Despite this, 5 out of 6 SNPs (V771M, V825I, I883M, E1172D, R1587K) predicted increased risk of IHD.
|
17951323 |
2008 |
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two polymorphisms were associated with plasma levels of ApoA1, 1 in the promoter (C-564T) and 1 in the coding (R1587K) regions, whereas only 1 polymorphism (R219K) was associated with the risk of MI.
|
14962947 |
2004 |