|
B-Cell Lymphomas
|
|
0.010 |
GeneticVariation
|
BEFREE |
A coding <i>TNFAIP3</i> variant, namely rs2230926, has been previously linked to B cell non-Hodgkin's lymphoma (NHL) development in patients with Sjogren's syndrome (SS) of French and UK origin.
|
30662920 |
2018 |
|
Childhood Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
A germline and coding polymorphism (rs2230926) of TNFAIP3 (A20), a central gatekeeper of nuclear factor-kappa B (NF-kB) activation, was recently found associated with primary Sjögren's syndrome (pSS)-associated lymphoma in a French cohort.We aimed to replicate this association.
|
26338037 |
2016 |
|
Adult Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
A germline and coding polymorphism (rs2230926) of TNFAIP3 (A20), a central gatekeeper of nuclear factor-kappa B (NF-kB) activation, was recently found associated with primary Sjögren's syndrome (pSS)-associated lymphoma in a French cohort.We aimed to replicate this association.
|
26338037 |
2016 |
|
Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
A germline and coding polymorphism (rs2230926) of TNFAIP3 (A20), a central gatekeeper of nuclear factor-kappa B (NF-kB) activation, was recently found associated with primary Sjögren's syndrome (pSS)-associated lymphoma in a French cohort.We aimed to replicate this association.
|
26338037 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
A higher risk to develop SLE was observed for rs2230926 (<i>P</i> = 0.02, OR = 1.92).
|
31534975 |
2019 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
A20 rs2230926 TG genotype and rs146534657 AG genotype may be related to poor outcome in RA patients.
|
26143186 |
2015 |
|
Lung Diseases, Interstitial
|
|
0.010 |
GeneticVariation
|
BEFREE |
And rs2230926 and rs5029939 were significantly associated with interstitial lung disease (ILD) in PM/DM and PM patients (P(c) = 0.04 and P(c) = 0.016; P(c) = 0.02 and P(c) = 0.03, respectively).
|
25337792 |
2014 |
|
Adult type dermatomyositis
|
|
0.010 |
GeneticVariation
|
BEFREE |
And rs2230926 and rs5029939 were significantly associated with interstitial lung disease (ILD) in PM/DM and PM patients (P(c) = 0.04 and P(c) = 0.016; P(c) = 0.02 and P(c) = 0.03, respectively).
|
25337792 |
2014 |
|
Dermatomyositis
|
|
0.010 |
GeneticVariation
|
BEFREE |
And rs2230926 and rs5029939 were significantly associated with interstitial lung disease (ILD) in PM/DM and PM patients (P(c) = 0.04 and P(c) = 0.016; P(c) = 0.02 and P(c) = 0.03, respectively).
|
25337792 |
2014 |
|
Hepatitis B, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association between TNFAIP3 nonsynonymous single-nucleotide polymorphism rs2230926 and chronic hepatitis B virus infection in a Chinese Han population.
|
25890346 |
2015 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Associations of TNFAIP3 rs2230926 (p=1.43 × 10(-3)) and TNIP1 rs10036748 (p=4.33 × 10(-3)) with SLE were replicated in our study.
|
23911423 |
2013 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
Furthermore, an association was found between the two allele of rs2230926 and RA in all study subjects (OR 1.390, 95% CI 1.214-2.331, p=1.9 × 10(-6)).
|
22402800 |
2012 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.
|
27399966 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
|
Sjogren's Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
Genotyping of the most common coding polymorphism, rs2230926, in the MADGC collection and additional control individuals revealed a significant association with Sjögren's syndrome (OR=3.38, P=0.038), Crohn's disease (OR=2.25, P=0.041), psoriasis (OR=0.037, P=0.036) and RA (OR=1.9, P=0.025).
|
21326317 |
2011 |
|
Crohn Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotyping of the most common coding polymorphism, rs2230926, in the MADGC collection and additional control individuals revealed a significant association with Sjögren's syndrome (OR=3.38, P=0.038), Crohn's disease (OR=2.25, P=0.041), psoriasis (OR=0.037, P=0.036) and RA (OR=1.9, P=0.025).
|
21326317 |
2011 |
|
Psoriasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Genotyping of the most common coding polymorphism, rs2230926, in the MADGC collection and additional control individuals revealed a significant association with Sjögren's syndrome (OR=3.38, P=0.038), Crohn's disease (OR=2.25, P=0.041), psoriasis (OR=0.037, P=0.036) and RA (OR=1.9, P=0.025).
|
21326317 |
2011 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
Genotyping of the most common coding polymorphism, rs2230926, in the MADGC collection and additional control individuals revealed a significant association with Sjögren's syndrome (OR=3.38, P=0.038), Crohn's disease (OR=2.25, P=0.041), psoriasis (OR=0.037, P=0.036) and RA (OR=1.9, P=0.025).
|
21326317 |
2011 |
|
Adult Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
However, the rs2230926 variant allele seems to confer a higher risk to develop lymphoma in pSS patients, while in RA patients, the presence of RF resulted significantly associated with the variant allele.
|
31534975 |
2019 |
|
Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
However, the rs2230926 variant allele seems to confer a higher risk to develop lymphoma in pSS patients, while in RA patients, the presence of RF resulted significantly associated with the variant allele.
|
31534975 |
2019 |
|
Childhood Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
However, the rs2230926 variant allele seems to confer a higher risk to develop lymphoma in pSS patients, while in RA patients, the presence of RF resulted significantly associated with the variant allele.
|
31534975 |
2019 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.
|
26663301 |
2016 |
|
Primary Sjögren's syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
In both cohorts, the rs2230926 missense polymorphism was not associated with pSS.
|
26338037 |
2016 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis demonstrates that TNFAIP3 gene polymorphisms (rs2230926 and rs5029937) are associated with the increased risk of RA.
|
28888761 |
2017 |