Regarding interaction with environmental factors, <i>ABCG2</i> rs2231142 and the first-degree family history of cancer and <i>XPC</i> rs2607775 or <i>ABCG2</i> rs2622621 and lymph node metastases status demonstrated significant interactions.
Concurrent effects of ABCB1 C3435T, ABCG2 C421A, and XRCC1 Arg194Trp genetic polymorphisms with risk of cancer, clinical output, and response to treatment with imatinib mesylate in patients with chronic myeloid leukemia.
No associations were observed between the BCRP C421A polymorphism and clinicopathologic or epidemiologic factors, including age, gender, tumor grade, stage, cigarette smoking, family history of cancer and body mass index.