rs2234918, OPRD1

N. diseases: 5
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Heroin Dependence
CUI: C0019337
Disease: Heroin Dependence
0.020 GeneticVariation BEFREE The genotype distribution and allelic frequency analyses showed that the minor C allele of rs2234918 in OPRD1 is over-represented in the HD group (P = .006 and P = .002, respectively). 30171993 2019
Opiate Addiction
CUI: C0524662
Disease: Opiate Addiction
0.020 GeneticVariation BEFREE Haplotype analyses with six tag SNPs indicated that a specific haplotype GCAACT, which harbors G80T G-allele and C921T C-allele, was significantly associated with AD (chi(2)=14.82, degrees of freedom (d.f.)=1, P<0.001), CD (chi(2)=9.19, d.f.=1, P=0.002) and OD (chi(2)=20.68, d.f.=1, P<0.001). 17622222 2008
Heroin Dependence
CUI: C0019337
Disease: Heroin Dependence
0.020 GeneticVariation BEFREE One study in a German population found that OPRD1 921T > C was associated with heroin dependence. 12116270 2002
Opiate Addiction
CUI: C0524662
Disease: Opiate Addiction
0.020 GeneticVariation BEFREE Previous study of a variant at the OPRD1 locus, T921C, has shown association with opioid dependence. 10982041 2000
Agnosia for Pain
CUI: C0563625
Disease: Agnosia for Pain
0.010 GeneticVariation BEFREE Moreover, in males, variability in morphine analgesia to rectal thermal stimulation was associated with OPRD1 polymorphisms: rs2234918 (p = 0.01) and rs533123 (p = 0.046). 28084056 2017
Alcoholic Intoxication, Chronic
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
0.010 GeneticVariation BEFREE Haplotype analyses with six tag SNPs indicated that a specific haplotype GCAACT, which harbors G80T G-allele and C921T C-allele, was significantly associated with AD (chi(2)=14.82, degrees of freedom (d.f.)=1, P<0.001), CD (chi(2)=9.19, d.f.=1, P=0.002) and OD (chi(2)=20.68, d.f.=1, P<0.001). 17622222 2008
Cocaine Dependence
CUI: C0600427
Disease: Cocaine Dependence
0.010 GeneticVariation BEFREE Haplotype analyses with six tag SNPs indicated that a specific haplotype GCAACT, which harbors G80T G-allele and C921T C-allele, was significantly associated with AD (chi(2)=14.82, degrees of freedom (d.f.)=1, P<0.001), CD (chi(2)=9.19, d.f.=1, P=0.002) and OD (chi(2)=20.68, d.f.=1, P<0.001). 17622222 2008