rs2237892, KCNQ1

N. diseases: 16
Disease: Gestational Diabetes ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.040 GeneticVariation BEFREE The study demonstrated for the first time that the KCNQ1 rs2237892 polymorphism was associated with GDM and glucose levels in Chinese women. 26039078 2015
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.040 GeneticVariation BEFREE These polymorphisms were in or near the following genes: TCF7L2 (rs7903146), MTNR1B (rs10830963), IGF2BP2 (rs4402960), KCNJ11 (rs5219), CDKAL1 (rs7754840), KCNQ1 (rs2237892 and rs2237895) and GCK (rs4607517); while no association was found for PPARG with GDM risk. 23029294 2012
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.040 GeneticVariation BEFREE Furthermore, rs2237892 and rs2237895 were nominally associated with a decreased insulinogenic index at the time of GDM diagnosis (p = 0.025 and p = 0.037), whereas no association was observed with measures of insulin resistance. 20606385 2010
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.040 GeneticVariation BEFREE KCNQ1 polymorphisms of rs2237892 and rs2237895 were significantly associated with the risk of GDM (P = 0.003 and 0.005, respectively). 19850681 2010