rs2240308, AXIN2

N. diseases: 18
Disease: Primary malignant neoplasm of lung ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Primary malignant neoplasm of lung
CUI: C1306460
Disease: Primary malignant neoplasm of lung
0.060 GeneticVariation BEFREE However, stratified analysis by cancer type showed evidence that rs2240308 C/T polymorphism had a lower risk in lung cancer (OR, 0.76; 95% CI, 0.63-0.92; P<sub>heterogeneity</sub>  = 0.865) and prostate cancer (OR, 0.54; 95% CI, 0.35-0.84; P<sub>heterogeneity</sub>  = 0.088) by heterozygote comparison. 31038806 2019
Primary malignant neoplasm of lung
CUI: C1306460
Disease: Primary malignant neoplasm of lung
0.060 GeneticVariation BEFREE Moreover, the rs2240308 variant exhibited a significant association with a decreased risk of lung cancer and prostate cancer. 28043155 2019
Primary malignant neoplasm of lung
CUI: C1306460
Disease: Primary malignant neoplasm of lung
0.060 GeneticVariation BEFREE Three out of seven studied polymorphic sites showed a strong protective effect in subjects having mutant genotype for Axin2 148 C >T and heterozygous genotype for 1365 G > A and 1712 + 19 G > T towards lung cancer risk. 28378643 2017
Primary malignant neoplasm of lung
CUI: C1306460
Disease: Primary malignant neoplasm of lung
0.060 GeneticVariation BEFREE AXIN2 polymorphism rs2240308 was also associated with decreased cancer risk under all five models in lung cancer. 25974148 2015
Primary malignant neoplasm of lung
CUI: C1306460
Disease: Primary malignant neoplasm of lung
0.060 GeneticVariation BEFREE Findings from this study suggest that Axin2 exon1 T148C polymorphism (rs2240308) contributes to increased susceptibility to lung cancer in Chinese population. 25091576 2014
Primary malignant neoplasm of lung
CUI: C1306460
Disease: Primary malignant neoplasm of lung
0.060 GeneticVariation BEFREE These results suggest that the AXIN2 Pro50Ser SNP is associated with development of lung cancer as a protective SNP, while an association between the AXIN2 SNP and risk of colorectal cancer and of head and neck cancer was not observed. 16820935 2006