|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Importantly, ATG16L1 A300T and NOD2 variants were not associated with serologic responses in healthy controls and unoperated UC patients.
|
30265311 |
2019 |
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ATG16L1 gene was genotyped for ten different SNPs using DNA extracted from peripheral blood of 234 patients with Crohn's disease (CD), 249 patients with ulcerative colitis (UC) and 393 healthy controls The SNPs rs2241880, rs4663396, rs3792106, rs10210302, rs3792109, rs2241877, rs6737398, rs11682898, rs4663402 and rs4663421 were genotyped using the Sequenom MassArray platform.
|
28542425 |
2017 |
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).
|
20082483 |
2010 |
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - Arg381Gln (rs11209026) and ATG16L1 - Thr300Ala (rs2241880).
|
20082483 |
2010 |
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ATG16L1 T300A polymorphism contributes to susceptibility to CD and UC in adults, but different in children, which implicates a role for autophagy in the pathogenesis of IBD.
|
20222171 |
2010 |
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, our results confirm the ATG16L1 rs2241880 and IRGM rs13361189 and rs4958847 polymorphisms as important markers for CD susceptibility and indicate that these variants are also associated with UC.
|
19491842 |
2009 |
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Thr300Ala polymorphism is associated with CD, regardless of the CARD15 or IL23R status, but not with UC.
|
19575361 |
2009 |
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We genotyped 1028 IBD patients, including 443 CD and 347 ulcerative colitis (UC) non-Jewish cases, 238 (183 CD and 55 UC) Jewish cases, and 1005 ethnically matched control subjects for 18 and 11 variants, respectively, in the IL-23R and ATG16L1 genes, including the IL-23R (R381Q) and ATG16L1 (T216A) variants, previously associated with CD.
|
19276991 |
2009 |
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
With respect to ATG16L1, the G allele of SNP rs2241880 has been shown in multiple association studies to confer strong risk for CD, although its association with UC remains more debatable.
|
18366306 |
2008 |
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We confirm the strong association between T300A and CD, specifically ileal subphenotype, and also report the first strong association of this variant with UC.
|
18671817 |
2008 |
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Five hundred eighteen Dutch white IBD patients (311 CD and 207 UC, including 176 trios of patients with both parents), 508 celiac disease patients, and 893 healthy controls were studied for association with the rs11209026 (IL23R) and rs2241880 (ATG16L1) single nucleotide polymorphisms (SNP).
|
18047540 |
2008 |
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Together with the lack of association between rs2241880 and ulcerative colitis (P > 0.4), these data suggest that the underlying biological process may be specific to Crohn disease.
|
17200669 |
2007 |
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Allele frequencies of rs11209026 and rs2241880 were determined in 496 CD patients, 466 ulcerative colitis (UC) patients, and 591 controls.
|
17894849 |
2007 |