|
Squamous cell carcinoma of esophagus
|
|
0.800 |
GeneticVariation
|
BEFREE |
Meta-analysis found significant associations between rs2274223 and ESCC under all analyzed genetic models.
|
30666517 |
2019 |
|
Squamous cell carcinoma of esophagus
|
|
0.800 |
GeneticVariation
|
BEFREE |
In additional, five variants on five genes were rated as strong cumulative epidemiological evidence for a nominally significant association with EC and ESCC risk, including CYP1A1 rs1048943, EGF rs444903, HOTAIR rs920778, MMP2 rs243865, and PLCE1 rs2274223, 10 variants were rated as moderate, and 18 variants were rated as weak.
|
30793520 |
2019 |
|
Squamous cell carcinoma of esophagus
|
|
0.800 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrated that PLCE1 rs2274223 A > G polymorphism may be associated with increased susceptibility to cancer, especially for ESCC.
|
25614244 |
2015 |
|
Squamous cell carcinoma of esophagus
|
|
0.800 |
GeneticVariation
|
BEFREE |
We observed that the rs2274223 polymorphism was associated with an increased risk of ESCC in this Korean case-control study and that age may modify the association between the rs13042395 polymorphism and the risk of ESCC.
|
24152165 |
2015 |
|
Squamous cell carcinoma of esophagus
|
|
0.800 |
GeneticVariation
|
BEFREE |
So, we aimed to replicate association of two previously reported non-synonymous polymorphisms (rs2274223A>G and rs3765524C>T) from haplotype block 10 and evaluated a novel variant (rs7922612C>T) from haplotype block 2 of PLCE1 with susceptibility and prognosis of ESCC in northern Indian population.
|
25139097 |
2014 |
|
Squamous cell carcinoma of esophagus
|
|
0.800 |
GeneticVariation
|
BEFREE |
Consistent with the previous study, loci at rs2074356 and rs2274223 could increase the risk of ESCC, furthermore, there were significant interactions between HPV sero-status and the susceptibility loci on the risk of ESCC.
|
25008389 |
2014 |
|
Squamous cell carcinoma of esophagus
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, PLCE1 rs2274223 polymorphism may be used as a potential biomarker for DTC susceptibility particularly for ESCC and GCA in the Chinese population.
|
24874112 |
2014 |
|
Squamous cell carcinoma of esophagus
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
|
25129146 |
2014 |
|
Squamous cell carcinoma of esophagus
|
|
0.800 |
GeneticVariation
|
BEFREE |
In this meta-analysis, the PLCE1 rs2274223 polymorphism was confirmed to have a statistically significant association with an increasing risk of ESCC and gastric cancer.
|
23826241 |
2013 |
|
Squamous cell carcinoma of esophagus
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our meta-analysis results indicated that PLCE1 rs2274223 G allele significantly contributed to the risk of ESCC and GCA, especially in Chinese population.
|
23874915 |
2013 |
|
Squamous cell carcinoma of esophagus
|
|
0.800 |
GeneticVariation
|
BEFREE |
SNP rs2274223 was independently associated with increased risk of ESCC (adjusted odds ratio [OR], 2.80; 95% confidence interval [95% CI], 1.45-5.39 for GG vs. AA), and SNP rs2274224 was found to be associated with decreased risk of ESCC (adjusted OR, 0.65; 95% CI, 0.46-0.91 for CG vs. CC).
|
23688607 |
2013 |
|
Squamous cell carcinoma of esophagus
|
|
0.800 |
GeneticVariation
|
BEFREE |
Especially, the risk effects of rs2274223 were more evident in poor differentiation and advanced clinical stages of Kazakh ESCC.
|
23981775 |
2013 |
|
Squamous cell carcinoma of esophagus
|
|
0.800 |
GeneticVariation
|
BEFREE |
In contrast to the modulation of the risk of ESCC in Asians, it is unlikely that the PLCE1 rs2274223 and RFT2 13042395 SNPs play a role in EAC or ESCC susceptibility in Dutch Caucasians.
|
23222411 |
2013 |
|
Squamous cell carcinoma of esophagus
|
|
0.800 |
GeneticVariation
|
BEFREE |
PLCE1 SNP rs2274223 A>G change may reduce gene expression, and the variant G genotypes might contribute to risk of ESCC.
|
22203178 |
2012 |
|
Squamous cell carcinoma of esophagus
|
|
0.800 |
GeneticVariation
|
BEFREE |
These results highlighted the role of a genetic factor in ESCC and suggested that the PLCε1 rs2274223 SNP might be an effective genetic marker to assess the risk of ESCC in individuals with a UGIC family history from a region of high incidence in northern China.
|
23079034 |
2012 |
|
Squamous cell carcinoma of esophagus
|
|
0.800 |
GeneticVariation
|
BEFREE |
To the best of our knowledge, this is the first study to report an association between rs2274223 and rs4072037 and the risk of oesophageal squamous cell carcinoma in a Caucasian population.
|
22805490 |
2012 |
|
Squamous cell carcinoma of esophagus
|
|
0.800 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (SNP, rs2274223) in PLCE1 has been identified as a novel susceptibility locus in genome-wide association studies (GWAS) of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA) that share similar risk factors with SCCHN.
|
21689432 |
2011 |
|
Squamous cell carcinoma of esophagus
|
|
0.800 |
GeneticVariation
|
BEFREE |
A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 x 10(-9); per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 x 10(-9); OR = 1.34).
|
20729852 |
2010 |