rs2275913, IL17A

N. diseases: 105
Disease: Osteoarthritis, Knee ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Osteoarthritis, Knee
CUI: C0409959
Disease: Osteoarthritis, Knee
0.040 GeneticVariation BEFREE Based on our findings, rs2275913 and rs763780 could be considered as protective and risk factors for knee osteoarthritis, respectively. 31144366 2019
Osteoarthritis, Knee
CUI: C0409959
Disease: Osteoarthritis, Knee
0.040 GeneticVariation BEFREE The aim of this study was to determine whether IL-17A(rs2275913) and IL-17F(rs763780) polymorphisms confer susceptibility to knee osteoarthritis. 31842922 2019
Osteoarthritis, Knee
CUI: C0409959
Disease: Osteoarthritis, Knee
0.040 GeneticVariation BEFREE The experimental results indicated that the polymorphism in IL-17 gene rs2275913 site were related to knee OA risk after the adjustment of BMI, sex, age, smoking and drinking status (AA vs. GG: odds ratio (OR), 1.411; 95% confidence interval (CI), 1.021-1.950; P = 0.040; A allele vs. G allele: OR, 1.192; P = 0.037; 95% CI, 1.012-1.404;). 30658595 2019
Osteoarthritis, Knee
CUI: C0409959
Disease: Osteoarthritis, Knee
0.040 GeneticVariation BEFREE The three-SNP haplotype (rs2275913-rs763780-rs1889570) G-C-A confers predisposition to hip (p < 0.005) but not knee OA. 31042000 2019