|
Duodenal Ulcer
|
|
0.860 |
GeneticVariation
|
BEFREE |
Recently, three genome-wide association studies have identified the PSCA (prostate stem cell antigen) rs2294008 polymorphism (C > T) associated with susceptibility to gastric cancer, bladder cancer, and duodenal ulcers, highlighting its critical role in disease pathogenesis.
|
27001215 |
2016 |
|
Duodenal Ulcer
|
|
0.860 |
GeneticVariation
|
BEFREE |
The T allele of rs2294008 encodes a translation initiation codon upstream of the reported site and changes protein localization from the cytoplasm to the cell surface. rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10(-10)).
|
22387998 |
2012 |
|
Duodenal Ulcer
|
|
0.860 |
GeneticVariation
|
GWASCAT |
The T allele of rs2294008 encodes a translation initiation codon upstream of the reported site and changes protein localization from the cytoplasm to the cell surface. rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10(-10)).
|
22387998 |
2012 |
|
Duodenal Ulcer
|
|
0.860 |
GeneticVariation
|
BEFREE |
Frequency of PSCA rs2294008 C/C genotype in duodenal ulcer was 36.1%, which was significantly higher than those with gastric cancer (12.4%), gastric ulcer (19.0%), gastritis (10.7%), and H. pylori-negatives (19.5%) (p < .001).
|
25582162 |
2015 |
|
Duodenal Ulcer
|
|
0.860 |
GeneticVariation
|
BEFREE |
Genomic DNA from 603 Spanish patients with primary GC, 139 with DU and 675 healthy controls was typed for the PSCA rs2294008C>T polymorphism by PCR-TaqMan assays.
|
25721731 |
2015 |
|
Duodenal Ulcer
|
|
0.860 |
GeneticVariation
|
BEFREE |
Cumulative evidence of an association was graded as strong for rs2294008 [odds ratio (OR) = 1.32, P = 5.1 × 10-33], rs2976392 (OR = 1.29, P = 1.8 × 10-8), rs9297976 (OR = 0.75, P = 1.4 × 10-7), rs2976391 (OR = 1.38, P = 6.1 × 10-5) and rs138377917 (OR = 0.53, P = 0.008) with gastric cancer, rs2294008 with bladder cancer (OR = 1.15, P = 8.0 × 10-19), gastritis (OR = 1.35, P = 1.2 × 10-5), duodenal ulcer (OR = 0.68, P = 2.4 × 10-57) and gastric ulcer (OR = 0.88, P = 1.7 × 10-7).
|
30407486 |
2019 |
|
Duodenal Ulcer
|
|
0.860 |
GeneticVariation
|
BEFREE |
Our study confirms an association between the PSCA rs2294008 C-allele and the risk of DU in a Japanese population.
|
31839644 |
2019 |
|
Duodenal Ulcer
|
|
0.860 |
GeneticVariation
|
GWASDB |
The T allele of rs2294008 encodes a translation initiation codon upstream of the reported site and changes protein localization from the cytoplasm to the cell surface. rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10(-10)).
|
22387998 |
2012 |
|
Duodenal Ulcer
|
|
0.860 |
GeneticVariation
|
BEFREE |
From these results we conclude that the PSCA rs2294008 polymorphism is involved in the susceptibility to GC and DU, as well as in the prognosis of the diffuse-type of GC in Caucasians.
|
25721731 |
2015 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
PSCA rs2294008/rs2976392 showed a significant, multiplicative interaction with H. pylori infection in risk of GC.
|
28220687 |
2017 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Recently, two genome-wide association studies identified a significant association between the prostate stem cell antigen (PSCA) rs2294008 (C>T) polymorphism and risk of diffuse-type of gastric cancer in Asians and bladder cancer in Caucasians, respectively.
|
20083643 |
2010 |
|
Malignant neoplasm of urinary bladder
|
|
0.800 |
GeneticVariation
|
BEFREE |
Based on the statistical evidence, we can draw a conclusion that the rs2294008 polymorphism of PSCA gene is likely to play a role in cancer carcinogenesis, especially in gastric cancer and bladder cancer.
|
26308216 |
2015 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The two loci of PSCA (rs2294008 and rs2976392) were both significantly associated with GC susceptibility and in linkage disequilibrium.
|
22426141 |
2012 |
|
Carcinoma of bladder
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, the results suggest that the PSCA rs2294008 (C>T) polymorphism is a risk factor for bladder cancer development.
|
25117309 |
2014 |
|
Malignant neoplasm of urinary bladder
|
|
0.800 |
GeneticVariation
|
GWASDB |
Our data identify rs2294008 as a new bladder cancer susceptibility locus.
|
19648920 |
2009 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The C allele of rs2294008 at PSCA was associated with increased risk of duodenal ulcer (odds ratio (OR) = 1.84; P = 3.92 × 10(-33)) in a recessive model but was associated with decreased risk of gastric cancer (OR = 0.79; P = 6.79 × 10(-12)), as reported previously.
|
22387998 |
2012 |
|
Carcinoma of bladder
|
|
0.800 |
GeneticVariation
|
GWASCAT |
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
|
20972438 |
2010 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Recently, three genome-wide association studies have identified the PSCA (prostate stem cell antigen) rs2294008 polymorphism (C > T) associated with susceptibility to gastric cancer, bladder cancer, and duodenal ulcers, highlighting its critical role in disease pathogenesis.
|
27001215 |
2016 |
|
Malignant neoplasm of urinary bladder
|
|
0.800 |
GeneticVariation
|
BEFREE |
For the PSCA rs2294008 polymorphism, when stratified by type of cancer, the results were significant especially in gastric cancer and bladder cancer.
|
28881685 |
2017 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The variant C allele of the reference SNP rs2294008 in the PSCA gene was associated with a significantly reduced risk of GC (per allele-adjusted odds ratio [aOR], 0.51; 95% confidence interval [CI], 0.33-0.77; P = .002).
|
24962126 |
2014 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies.
|
26701879 |
2017 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Previous genomewide association studies identified prostate stem cell antigen (PSCA) as a gastric cancer (GC) susceptibility gene and showed an association between GC and the T allele of the single nucleotide polymorphism rs2294008 (C/T) in this gene.
|
25727947 |
2015 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
However, subtype-specific associations were observed for gastric cardia adenocarcinomas at MUC1/TRIM46/1q22 rs2070803 [HRAA versus GA+GG = 2.16; 95% confidence interval (CI) = 1.24-3.78; P = 0.0068] and LTA/TNF/6p21.33 rs1799724 (HRTT+CT versus CC = 1.30; 95% CI = 1.07-1.57; P = 0.0077), and for diffuse-type GC at PSCA/8q24.3 rs2294008 (HRTT versus CT+CC = 1.99; 95% CI = 1.33-2.97; P = 7.8E-04).
|
29028942 |
2017 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU).
|
31839644 |
2019 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Two single nucleotide polymorphisms (SNPs) (rs2976392 and rs2294008) in the PSCA gene were recently identified as the susceptibility loci of gastric cancer, especially in diffuse type.
|
20131315 |
2010 |