Duodenal Ulcer
|
|
0.860 |
GeneticVariation
|
BEFREE |
Recently, three genome-wide association studies have identified the PSCA (prostate stem cell antigen) rs2294008 polymorphism (C > T) associated with susceptibility to gastric cancer, bladder cancer, and duodenal ulcers, highlighting its critical role in disease pathogenesis.
|
27001215 |
2016 |
Duodenal Ulcer
|
|
0.860 |
GeneticVariation
|
BEFREE |
The T allele of rs2294008 encodes a translation initiation codon upstream of the reported site and changes protein localization from the cytoplasm to the cell surface. rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10(-10)).
|
22387998 |
2012 |
Duodenal Ulcer
|
|
0.860 |
GeneticVariation
|
BEFREE |
Frequency of PSCA rs2294008 C/C genotype in duodenal ulcer was 36.1%, which was significantly higher than those with gastric cancer (12.4%), gastric ulcer (19.0%), gastritis (10.7%), and H. pylori-negatives (19.5%) (p < .001).
|
25582162 |
2015 |
Duodenal Ulcer
|
|
0.860 |
GeneticVariation
|
BEFREE |
Genomic DNA from 603 Spanish patients with primary GC, 139 with DU and 675 healthy controls was typed for the PSCA rs2294008C>T polymorphism by PCR-TaqMan assays.
|
25721731 |
2015 |
Duodenal Ulcer
|
|
0.860 |
GeneticVariation
|
BEFREE |
Cumulative evidence of an association was graded as strong for rs2294008 [odds ratio (OR) = 1.32, P = 5.1 × 10-33], rs2976392 (OR = 1.29, P = 1.8 × 10-8), rs9297976 (OR = 0.75, P = 1.4 × 10-7), rs2976391 (OR = 1.38, P = 6.1 × 10-5) and rs138377917 (OR = 0.53, P = 0.008) with gastric cancer, rs2294008 with bladder cancer (OR = 1.15, P = 8.0 × 10-19), gastritis (OR = 1.35, P = 1.2 × 10-5), duodenal ulcer (OR = 0.68, P = 2.4 × 10-57) and gastric ulcer (OR = 0.88, P = 1.7 × 10-7).
|
30407486 |
2019 |
Duodenal Ulcer
|
|
0.860 |
GeneticVariation
|
BEFREE |
Our study confirms an association between the PSCA rs2294008 C-allele and the risk of DU in a Japanese population.
|
31839644 |
2019 |
Duodenal Ulcer
|
|
0.860 |
GeneticVariation
|
BEFREE |
From these results we conclude that the PSCA rs2294008 polymorphism is involved in the susceptibility to GC and DU, as well as in the prognosis of the diffuse-type of GC in Caucasians.
|
25721731 |
2015 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
PSCA rs2294008/rs2976392 showed a significant, multiplicative interaction with H. pylori infection in risk of GC.
|
28220687 |
2017 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Recently, two genome-wide association studies identified a significant association between the prostate stem cell antigen (PSCA) rs2294008 (C>T) polymorphism and risk of diffuse-type of gastric cancer in Asians and bladder cancer in Caucasians, respectively.
|
20083643 |
2010 |
Malignant neoplasm of urinary bladder
|
|
0.800 |
GeneticVariation
|
BEFREE |
Based on the statistical evidence, we can draw a conclusion that the rs2294008 polymorphism of PSCA gene is likely to play a role in cancer carcinogenesis, especially in gastric cancer and bladder cancer.
|
26308216 |
2015 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The two loci of PSCA (rs2294008 and rs2976392) were both significantly associated with GC susceptibility and in linkage disequilibrium.
|
22426141 |
2012 |
Carcinoma of bladder
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, the results suggest that the PSCA rs2294008 (C>T) polymorphism is a risk factor for bladder cancer development.
|
25117309 |
2014 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The C allele of rs2294008 at PSCA was associated with increased risk of duodenal ulcer (odds ratio (OR) = 1.84; P = 3.92 × 10(-33)) in a recessive model but was associated with decreased risk of gastric cancer (OR = 0.79; P = 6.79 × 10(-12)), as reported previously.
|
22387998 |
2012 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Recently, three genome-wide association studies have identified the PSCA (prostate stem cell antigen) rs2294008 polymorphism (C > T) associated with susceptibility to gastric cancer, bladder cancer, and duodenal ulcers, highlighting its critical role in disease pathogenesis.
|
27001215 |
2016 |
Malignant neoplasm of urinary bladder
|
|
0.800 |
GeneticVariation
|
BEFREE |
For the PSCA rs2294008 polymorphism, when stratified by type of cancer, the results were significant especially in gastric cancer and bladder cancer.
|
28881685 |
2017 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The variant C allele of the reference SNP rs2294008 in the PSCA gene was associated with a significantly reduced risk of GC (per allele-adjusted odds ratio [aOR], 0.51; 95% confidence interval [CI], 0.33-0.77; P = .002).
|
24962126 |
2014 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Previous genomewide association studies identified prostate stem cell antigen (PSCA) as a gastric cancer (GC) susceptibility gene and showed an association between GC and the T allele of the single nucleotide polymorphism rs2294008 (C/T) in this gene.
|
25727947 |
2015 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
However, subtype-specific associations were observed for gastric cardia adenocarcinomas at MUC1/TRIM46/1q22 rs2070803 [HRAA versus GA+GG = 2.16; 95% confidence interval (CI) = 1.24-3.78; P = 0.0068] and LTA/TNF/6p21.33 rs1799724 (HRTT+CT versus CC = 1.30; 95% CI = 1.07-1.57; P = 0.0077), and for diffuse-type GC at PSCA/8q24.3 rs2294008 (HRTT versus CT+CC = 1.99; 95% CI = 1.33-2.97; P = 7.8E-04).
|
29028942 |
2017 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU).
|
31839644 |
2019 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Two single nucleotide polymorphisms (SNPs) (rs2976392 and rs2294008) in the PSCA gene were recently identified as the susceptibility loci of gastric cancer, especially in diffuse type.
|
20131315 |
2010 |
Malignant neoplasm of urinary bladder
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, a joint effect of two PSCA SNPs, rs2294008 and rs2978974, suggests that both variants may be important for bladder cancer susceptibility, possibly through different mechanisms that influence the control of mRNA expression and interaction with regulatory factors.
|
22416122 |
2012 |
Carcinoma of bladder
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our meta-analysis supports that the PSCA gene variant rs2294008 polymorphism might contribute to individual susceptibility to bladder cancer.
|
31008939 |
2019 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
These findings supported that PSCA rs2294008 C > T and rs2976392 G > A polymorphisms may contribute to the susceptibility to gastric cancer, particular in non-cardia or diffused gastric cancer.
|
22481254 |
2012 |
Carcinoma of bladder
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our study showed that the rs2294008 polymorphism in the PSCA gene is associated with the risk of bladder cancer in a Korean population, providing evidence that it may contribute to bladder carcinogenesis regardless of ethnicity.
|
25374226 |
2014 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The rs2294008 polymorphism in PSCA increases the risk of noncardia gastric cancer and its precursors in white individuals but protects against proximal cancers.
|
21070776 |
2011 |