Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE We found that both rs2294008 (CT vs. CC, OR = 1.55, 95% CI = 1.20-1.99, <i>P</i><0.001 and CT+TT vs. CC, OR = 1.38, 95% CI = 1.09-1.74, <i>P</i>=0.008) and rs2976392 (GA vs. GG, OR = 1.61, 95% CI = 1.25-2.07, <i>P</i><0.001 and GA+AA vs. GG, OR = 1.52, 95% CI = 1.20-1.92, <i>P</i><0.001) were associated with an increased gastric cancer. 31416884 2019
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU). 31839644 2019
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE We conducted a case-control association study of <i>H. pylori</i>-infected gastritis and gastric cancer. rs2294008 was associated with the progression to chronic active gastritis (<i>P =</i> 9.4 × 10<sup>-5</sup>; odds ratio = 3.88, TT + TC vs CC genotype), but not with <i>H. pylori</i> infection <i>per se</i> nor with the progression from active gastritis to gastric cancer. 29423095 2018
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE PSCA rs2294008/rs2976392 showed a significant, multiplicative interaction with H. pylori infection in risk of GC. 28220687 2017
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE However, subtype-specific associations were observed for gastric cardia adenocarcinomas at MUC1/TRIM46/1q22 rs2070803 [HRAA versus GA+GG = 2.16; 95% confidence interval (CI) = 1.24-3.78; P = 0.0068] and LTA/TNF/6p21.33 rs1799724 (HRTT+CT versus CC = 1.30; 95% CI = 1.07-1.57; P = 0.0077), and for diffuse-type GC at PSCA/8q24.3 rs2294008 (HRTT versus CT+CC = 1.99; 95% CI = 1.33-2.97; P = 7.8E-04). 29028942 2017
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE In conclusion, the results indicated that the PSCA rs2294008 T and rs2976392 A alleles were low-penetrate risk factors for GCa in this study population. 26848528 2016
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE Recently, three genome-wide association studies have identified the PSCA (prostate stem cell antigen) rs2294008 polymorphism (C > T) associated with susceptibility to gastric cancer, bladder cancer, and duodenal ulcers, highlighting its critical role in disease pathogenesis. 27001215 2016
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE The PSCA rs2294008 C>T polymorphism may be acting through induction of gastric mucosal atrophy, finally leading to development of gastric ulcer and gastric cancer in PSCA rs2294008 T allele carriers, but not duodenal ulcer. 25582162 2015
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE Specifically, a significant increased stomach cancer risk was associated with PSCA rs2294008 (CT vs. CC: adjusted OR = 1.37, 95% CI = 1.07-1.74, and CT/TT vs.CC: adjusted OR = 1.30, 95% CI = 1.03-1.63), PSCA rs2976392 (AG vs. GG: adjusted OR = 1.30, 95% CI = 1.02-1.65, and AG/AA vs. GG: adjusted OR = 1.26, 95% CI = 1.00-1.59), or PLCE1 rs2274223 (AG vs. AA: adjusted OR = 1.48, 95% CI = 1.15-1.90, and AG/GG vs. AA: adjusted OR = 1.45, 95% CI = 1.14-1.84), respectively. 25658482 2015
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE From these results we conclude that the PSCA rs2294008 polymorphism is involved in the susceptibility to GC and DU, as well as in the prognosis of the diffuse-type of GC in Caucasians. 25721731 2015
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE Two recent genome-wide association studies in Asians have reported the association between the PSCA (prostate stem cell antigen) rs2294008C>T gene polymorphism and two Helicobacter pylori infection-related diseases such as gastric cancer (GC) and duodenal ulcer (DU). 25721731 2015
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE Previous genomewide association studies identified prostate stem cell antigen (PSCA) as a gastric cancer (GC) susceptibility gene and showed an association between GC and the T allele of the single nucleotide polymorphism rs2294008 (C/T) in this gene. 25727947 2015
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE In addition, our data indicate that rs2294008 of PSCA is involved in GC susceptibility and confer its effect primarily in noncardia tumors (OR = 1.30, 95% CI 1.12-1.53, P < 10(-4)). 24146278 2014
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE We found that the T allele of rs2294008, an intronic variant of the PSCA gene at 8q24 that was previously associated with an increased risk of gastric cancer, was inversely associated with a decreased risk of ESCC (odds ratio = 0.90; 95% confidence interval, 0.81-0.99; P = 0.034). 24654646 2014
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE The variant C allele of the reference SNP rs2294008 in the PSCA gene was associated with a significantly reduced risk of GC (per allele-adjusted odds ratio [aOR], 0.51; 95% confidence interval [CI], 0.33-0.77; P = .002). 24962126 2014
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE Polymorphisms of PSCA (rs2976392, rs2294008) and MUC1 (rs4072037) genes are associated with GC and HRAG. 25503145 2014
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE We analyzed 3 SNPs in the PSCA gene (rs2294008, rs9297976 and rs12155758) which were previously found to be associated with GC risk in Europeans. 24023815 2013
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE These results confirm the association between variation in the promoter region of PSCA and GC risk in Caucasians and also indicate that the rs2294008 variant is a similar risk factor for both the diffuse and intestinal-types of GC. 21681742 2012
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE Although modest limitations and potential bias cannot be eliminated, this meta-analysis suggests that PSCA -rs2294008C>T and -rs2976392G>A are potential factors of GC development for Eastern Asians, and future work may incorporate these findings and evaluate these variants as potential markers for screening and early diagnosis of GC. 22155405 2012
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE The C allele of rs2294008 at PSCA was associated with increased risk of duodenal ulcer (odds ratio (OR) = 1.84; P = 3.92 × 10(-33)) in a recessive model but was associated with decreased risk of gastric cancer (OR = 0.79; P = 6.79 × 10(-12)), as reported previously. 22387998 2012
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE The two loci of PSCA (rs2294008 and rs2976392) were both significantly associated with GC susceptibility and in linkage disequilibrium. 22426141 2012
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE These findings supported that PSCA rs2294008 C > T and rs2976392 G > A polymorphisms may contribute to the susceptibility to gastric cancer, particular in non-cardia or diffused gastric cancer. 22481254 2012
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE Our study suggested rs2294008 in the PSCA gene to be associated with increased risk of gastric cancer and rs2070803 in MUC1 to play a protective role in a Chinese population. 22938426 2012
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE Association of the PSCA rs2294008 C>T polymorphism with gastric cancer risk: evidence from a meta-analysis. 22938475 2012
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.100 GeneticVariation BEFREE If validated in further studies, PSCA rs2294008 could be useful marker of survival assessment and individualized clinical therapy for gastric cancer, particularly among the diffuse-type gastric cancer. 21064099 2011