|
Essential Hypertension
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polytropic Influence of <i>TRIB3</i> rs2295490 Genetic Polymorphism on Response to Antihypertensive Agents in Patients With Essential Hypertension.
|
30971918 |
2019 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
The gain-of-function Q84R polymorphism in TRIB3 is associated with increased risk of diabetes and atherosclerosis.
|
26855171 |
2016 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
The gain-of-function Q84R polymorphism in TRIB3 is associated with increased risk of diabetes and atherosclerosis.
|
26855171 |
2016 |
|
Endothelial dysfunction
|
|
0.010 |
GeneticVariation
|
BEFREE |
The relatively common TRIB3 Q84R polymorphism (rs2295490) has been associated with abnormal insulin signaling, endothelial dysfunction, insulin resistance, and pro-atherogenic phenotypes.
|
26253791 |
2015 |
|
Diabetic Nephropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
To determine whether the Q84R polymorphism (rs2295490), alone or in combination with smoking, contributes to the development of diabetic nephropathy, a case-control study was performed in 812 Chinese patients with type 2 diabetes.
|
25447894 |
2015 |
|
Polycystic Ovary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
TRB3 Q84R polymorphism is associated with obesity and especially glucose metabolism and not associated with polycystic ovary syndrome because of compositional characteristics of phenotype in Chinese PCOS women.
|
21492415 |
2011 |
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
TRB3 Q84R polymorphism is associated with obesity and especially glucose metabolism and not associated with polycystic ovary syndrome because of compositional characteristics of phenotype in Chinese PCOS women.
|
21492415 |
2011 |
|
Carotid Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
TRIB3 functional Q84R polymorphism is a risk factor for metabolic syndrome and carotid atherosclerosis.
|
19389818 |
2009 |
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation
|
BEFREE |
Individuals with the functional TRIB3 Q84R polymorphism are at risk for MetS.
|
19389818 |
2009 |
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In 100 additional type 2 diabetic patients who suffered from myocardial ischemia, age at myocardial ischemia was progressively and significantly (P = 0.03) reduced from Q84Q to Q84R to R84R individuals.
|
16123373 |
2005 |
|
Myocardial Ischemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In 100 additional type 2 diabetic patients who suffered from myocardial ischemia, age at myocardial ischemia was progressively and significantly (P = 0.03) reduced from Q84Q to Q84R to R84R individuals.
|
16123373 |
2005 |
|
Atherosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The gain-of-function Q84R polymorphism in TRIB3 is associated with increased risk of diabetes and atherosclerosis.
|
26855171 |
2016 |
|
Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The gain-of-function Q84R polymorphism in TRIB3 is associated with increased risk of diabetes and atherosclerosis.
|
26855171 |
2016 |
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated the combined role of single nucleotide polymorphisms (SNPs) affecting insulin signaling (ENPP1 K121Q, rs1044498; IRS1 G972R, rs1801278; TRIB3 Q84R, rs2295490) on CVD, age at myocardial infarction (MI), in vivo insulin sensitivity and in vitro insulin-stimulated nitric oxide synthase (NOS) activity.
|
23107043 |
2013 |
|
Cardiovascular Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated the combined role of single nucleotide polymorphisms (SNPs) affecting insulin signaling (ENPP1 K121Q, rs1044498; IRS1 G972R, rs1801278; TRIB3 Q84R, rs2295490) on CVD, age at myocardial infarction (MI), in vivo insulin sensitivity and in vitro insulin-stimulated nitric oxide synthase (NOS) activity.
|
23107043 |
2013 |
|
Cardiovascular Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
In humans, TRIB3 overactivity, due to TRIB3 overexpression or to Q84R genetic polymorphism, with R84 being a gain-of-function variant, may be involved in shaping the risk of insulin resistance, T2DM, and cardiovascular disease.
|
22577090 |
2012 |
|
Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
We wanted to replicate this latter association and, if so, to get deeper insights about the molecular mechanisms underlying the role of the TRIB3 Q84R polymorphism in atherosclerosis.
|
20693163 |
2011 |
|
Atherosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
We wanted to replicate this latter association and, if so, to get deeper insights about the molecular mechanisms underlying the role of the TRIB3 Q84R polymorphism in atherosclerosis.
|
20693163 |
2011 |
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
We have recently described a Q84R gain-of-function polymorphism of TRIB3 with the R84 variant being associated with insulin resistance and an earlier age at myocardial infarction.
|
18436806 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
Assessment of Human Tribbles Homolog 3 Genetic Variation (rs2295490) Effects on Type 2 Diabetes Patients with Glucose Control and Blood Pressure Lowering Treatment.
|
27793583 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
To determine whether the Q84R polymorphism (rs2295490), alone or in combination with smoking, contributes to the development of diabetic nephropathy, a case-control study was performed in 812 Chinese patients with type 2 diabetes.
|
25447894 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
In sample 1 (n=791), the association between TRIB3 Q84R and impaired glucose regulation (IGR; defined as impaired fasting glucose and/or impaired glucose tolerance and/or type 2 diabetes by OGTT) and insulin sensitivity (ISI), and its interplay with early-phase insulin secretion (i.e. disposition index [DI]) were analysed.
|
20393693 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
The objective of the study was to verify the association of TRIB3 Q84R with: 1) T2D, either subtyped or not according to age at diagnosis (early-onset, <45 yr, or >or= 45 yr); 2) insulin secretion and sensitivity in nondiabetic individuals; or 3) in vitro insulin secretion from isolated human islets.
|
18984671 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
In this Review, we discuss the role of relatively infrequent polymorphisms of genes that regulate insulin signaling (including the K121Q polymorphism of ENPP1, the G972R polymorphism of IRS1 and the Q84R polymorphism of TRIB3) in T2DM and other conditions related to insulin resistance.
|
19924153 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
However, the Q84R variant is associated with insulin resistance among T2DM</span> patients in Chinese population.
|
19291425 |
2009 |