|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, rs231775 polymorphism was also found to be significantly associated with susceptibility to type 2 diabetes mellitus (T2DM) in East Asians and South Asians.<b>Conclusions:</b> Our findings indicated that rs231775 and rs5742909 polymorphisms may serve as genetic biomarkers of T1DM, and rs231775 polymorphism may also serve as a genetic biomarker of T2DM.
|
30988065 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
CTLA4 rs231775 and TNF-αrs1800629 were not associated with T1D onset in the Brazilian population.
|
26782543 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a combined analysis, the summary per-allele odds ratio (OR) for T1D of the G49A and C60T polymorphism was 1.42 [95% confidence interval (CI): 1.31-1.53, P<10(-5)] and 1.23 (95% CI: 1.18-1.29, P<10(-5)), respectively.
|
24465825 |
2014 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrated that the G allele of rs231775 of CTLA-4 is a risk factor associated with increased T1D susceptibility.
|
23261825 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of PTPN22 C1858T and CTLA-4 A49G polymorphisms with Type 1 Diabetes in Croatians.
|
19815302 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The influence of polymorphisms of INS(-23Hph1), CTLA-4(T17A), and PTPN22(R620W) on development of persistent islet autoimmunity and progression to type 1 diabetes was evaluated by parametric models and by survival analyses.
|
19188433 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The authors performed a meta-analysis of 33 studies examining the association of type 1 diabetes mellitus with polymorphisms in the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) gene, including the A49G (29 comparisons), C(-318)T (three comparisons), and (AT)n microsatellite (six comparisons) polymorphisms.
|
15961581 |
2005 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Evaluated was the role of the CTLA4 exon 1 A49G polymorphism and its role as a risk factor for T1D in our population.
|
15301861 |
2004 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between IL-18 gene promoter polymorphisms and CTLA-4 gene 49A/G polymorphism in Japanese patients with type 1 diabetes.
|
14709415 |
2004 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The CTLA-4 49 A/G polymorphism was detected by the PCR-restriction fragment-length polymorphism (RFLP) method in 97 type 1 diabetic subjects and 20 patients with Graves' disease, a cohort which included 4 patients who also had type 1 diabetes.
|
12610047 |
2003 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
We report the association of CTLA-4 A49G variation (cytotoxic T-lymphocyte associated-4) to TID among Filipinos, consistent with some but not all previous reports in other ethnic groups.
|
12185534 |
2002 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
CTLA-4 49 A/G dimorphism and type 1 diabetes susceptibility: a French case-control study and segregation analysis. Evidence of a maternal effect.
|
12047362 |
2002 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
We performed case-control and family-based association studies to assess if the CTLA4 A49G and intron 1 C/T polymorphisms were associated with development of early onset type 1 diabetes in the Northern Ireland population.
|
11477480 |
2001 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The 49A/G dimorphism in exon 1 and the (AT)n in the 3' untranslated region of the CTLA-4 gene were significantly associated with type 1 diabetes.
|
11685455 |
2001 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no evidence that the CTLA-4 exon 1 polymorphism (49 A/G) confers genetic susceptibility to type 1 diabetes mellitus in our case-control study in Japanese subjects.
|
10619986 |
1999 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data indicate that CTLA-4 exon 1 position 49 A/G dimorphism was significantly associated with predisposition to IDDM in our Central Poland population, particularly in patients lacking the strongly predisposing DRB1 alleles.
|
9690057 |
1998 |