|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genetic variation in CTLA-4 gene with reference to rs231775 polymorphism contributes to an increased predisposition to HT and GD.
|
30771152 |
2019 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interactions among the SNPs of rs231775, rs231779 and rs3087243 significantly increase the susceptibility to GD.
|
30223781 |
2018 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
These data indicated that CTLA-4 exon-1 49 A/G polymorphism may be associated with patient response to radionuclide <sup>131</sup> I therapy in Graves' disease.
|
28776731 |
2018 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Some gene polymorphisms, such as <i>CTLA4</i> rs231775, human leukocyte antigen polymorphisms (<i>DRB1*03, DQA1*05</i>, and <i>DQB1*02</i>) might be associated with the high recurrence risk in GD patients.
|
29085334 |
2017 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
WITHDRAWN: Correlations of <i>CTLA-4</i> exon-1 rs231775A>G and promoter region rs5742909C>T polymorphisms with the therapeutic efficacy of <sup>131</sup>I radionuclide in Graves' disease.
|
28588051 |
2017 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, our data support that the rs3087243 and rs231775 polymorphisms within the <i>CTLA4</i> gene confer genetic susceptibility to GD.
|
29299173 |
2017 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our study was to investigate whether the CTLA4 polymorphisms, including -318C/T (rs5742909), +49A/G (rs231775), and CT60 (rs3087243), were associated with GD and HD in Han Chinese adults and children.
|
27111218 |
2016 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a comparison of frequencies of GG genotype, a significant association of 49A/G and CT60 polymorphism existed only for Graves' disease.
|
19559744 |
2009 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The CTLA-4 SNPs (-318C/T, 49A/G, and CT60A/G) were in the same haplotype block, and the CGG haplotype was associated with GD (P = 0.0071) but not GO.
|
18296657 |
2008 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Particularly, association of three polymorphic markers of CTLA4 gene, namely, C(-318)T, A49G, and (AT)n dinucleotide repeat, with Graves' disease was demonstrated in most of the population-based investigations.
|
18752454 |
2008 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Group-level data suggested significant associations with GD and HT for both A49G [odds ratios 1.49 (P = 6 x 10(-14)) and 1.29 (P = 0.001) per G allele, respectively] and CT60 [1.45 (P = 2 x 10(-9)) and 1.64 (P = 0.003) per G allele, respectively].
|
17504905 |
2007 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we evaluated the A/G(-1661), C/T(-318), A/G49 and A/G6230 single nucleotide polymorphisms (SNPs) of the cytotoxic T lymphocyte antigen 4 (CTLA-4) gene for association with Graves' disease (GD) in 126 Russian simplex families.
|
16297665 |
2006 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The G allele of A49G, the G allele of CT60, and the 280 allele of (AT)(n)-3'UTR microsatellite were significantly increased in patients with GD with thyroid-associated ophthalmopathy (TAO) compared to controls (p = 0.04, p = 0.03, and p = 0.02, respectively), however, we did not find any significant difference between TAO and non-TAO patients.
|
15785242 |
2005 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The CTLA-4 49 A/G polymorphism was detected by the PCR-restriction fragment-length polymorphism (RFLP) method in 97 type 1 diabetic subjects and 20 patients with Graves' disease, a cohort which included 4 patients who also had type 1 diabetes.
|
12610047 |
2003 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
(i) Allele G and G/G genotype confer genetic susceptibility to GD; (ii) CTLA-4 A49G polymorphism is not associated with the development of GO; (iii) different non-genetic factors may contribute to GO in different populations.
|
12534352 |
2003 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between GD and the G allele of the Thr17Ala polymorphism within the CTLA-4 gene ( CTLA4A/G ) was observed using unaffected sib controls ( P = 0.005).
|
10369864 |
1999 |