|
Alopecia Areata
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.
|
25608926 |
2015 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genetic variation in CTLA-4 gene with reference to rs231775 polymorphism contributes to an increased predisposition to HT and GD.
|
30771152 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, rs231775 polymorphism was also found to be significantly associated with susceptibility to type 2 diabetes mellitus (T2DM) in East Asians and South Asians.<b>Conclusions:</b> Our findings indicated that rs231775 and rs5742909 polymorphisms may serve as genetic biomarkers of T1DM, and rs231775 polymorphism may also serve as a genetic biomarker of T2DM.
|
30988065 |
2019 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Because the functional single-nucleotide polymorphism (SNP) rs231775 of the CTLA-4 gene is associated with autoimmune diseases and because of the critical role of the immune reaction in sepsis, we intended to examine the effect of this polymorphism on survival in patients with sepsis.
|
30310101 |
2018 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interactions among the SNPs of rs231775, rs231779 and rs3087243 significantly increase the susceptibility to GD.
|
30223781 |
2018 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
These data indicated that CTLA-4 exon-1 49 A/G polymorphism may be associated with patient response to radionuclide <sup>131</sup> I therapy in Graves' disease.
|
28776731 |
2018 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our present study indicates that CTLA-4 +49 G/A (rs231775) is associated with the susceptibility of autoimmune disease.
|
28384040 |
2017 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Some gene polymorphisms, such as <i>CTLA4</i> rs231775, human leukocyte antigen polymorphisms (<i>DRB1*03, DQA1*05</i>, and <i>DQB1*02</i>) might be associated with the high recurrence risk in GD patients.
|
29085334 |
2017 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
WITHDRAWN: Correlations of <i>CTLA-4</i> exon-1 rs231775A>G and promoter region rs5742909C>T polymorphisms with the therapeutic efficacy of <sup>131</sup>I radionuclide in Graves' disease.
|
28588051 |
2017 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, our data support that the rs3087243 and rs231775 polymorphisms within the <i>CTLA4</i> gene confer genetic susceptibility to GD.
|
29299173 |
2017 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our study was to investigate whether the CTLA4 polymorphisms, including -318C/T (rs5742909), +49A/G (rs231775), and CT60 (rs3087243), were associated with GD and HD in Han Chinese adults and children.
|
27111218 |
2016 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
CTLA4 rs231775 and TNF-αrs1800629 were not associated with T1D onset in the Brazilian population.
|
26782543 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a combined analysis, the summary per-allele odds ratio (OR) for T1D of the G49A and C60T polymorphism was 1.42 [95% confidence interval (CI): 1.31-1.53, P<10(-5)] and 1.23 (95% CI: 1.18-1.29, P<10(-5)), respectively.
|
24465825 |
2014 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrated that the G allele of rs231775 of CTLA-4 is a risk factor associated with increased T1D susceptibility.
|
23261825 |
2013 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
It has been found that CTLA4 +49A>G (rs231775), +6230G>A (rs3087243), and 11430G>A (rs11571319) polymorphisms are associated with susceptibility to many autoimmune diseases, and can down-regulate the inhibition of cellular immune response of CTLA4.
|
22811616 |
2012 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Its nonsynonymous polymorphism +49G > A (dbSNP: rs231775) has been linked to an elevated risk of T-cell-mediated autoimmune diseases, infectious diseases, and even carcinomas.
|
19778566 |
2010 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of PTPN22 C1858T and CTLA-4 A49G polymorphisms with Type 1 Diabetes in Croatians.
|
19815302 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The influence of polymorphisms of INS(-23Hph1), CTLA-4(T17A), and PTPN22(R620W) on development of persistent islet autoimmunity and progression to type 1 diabetes was evaluated by parametric models and by survival analyses.
|
19188433 |
2009 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interestingly, we have recently shown that an SNP in the CTLA-4 coding region (49A > G) is also associated with susceptibility to human cancer, but the risk allele for susceptibility to cancer (allele A) is the opposite of that found for susceptibility to autoimmune disease (allele G), which has been confirmed by a meta-analysis of reported studies.
|
19638588 |
2009 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a comparison of frequencies of GG genotype, a significant association of 49A/G and CT60 polymorphism existed only for Graves' disease.
|
19559744 |
2009 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results may therefore lend support to the hypothesis that humoral autoimmunity is correlated with 49A/G and CT60 polymorphisms of the CTLA-4 gene.
|
19559744 |
2009 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
While there was no association with vitiligo overall, the meta-analysis showed significant association of SNP rs231775 in that subgroup of vitiligo patients who also had other concomitant autoimmune diseases.
|
19175525 |
2009 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The CTLA-4 SNPs (-318C/T, 49A/G, and CT60A/G) were in the same haplotype block, and the CGG haplotype was associated with GD (P = 0.0071) but not GO.
|
18296657 |
2008 |
|
Autoimmune Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our observations of a higher frequency of the CTLA-4 + 49 A/G SNP in AH patients are in concordance with findings in other autoimmune disorders.
|
18081831 |
2008 |
|
Graves Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Particularly, association of three polymorphic markers of CTLA4 gene, namely, C(-318)T, A49G, and (AT)n dinucleotide repeat, with Graves' disease was demonstrated in most of the population-based investigations.
|
18752454 |
2008 |