|
Tuberculosis
|
|
0.060 |
GeneticVariation
|
BEFREE |
Further studies with larger sample sizes and consideration of gene-environment interactions should be conducted to elucidate the role of <i>IFNG</i> +874 T/A(rs2430561) polymorphism in tuberculosis susceptibility.
|
28881572 |
2017 |
|
Tuberculosis
|
|
0.060 |
GeneticVariation
|
BEFREE |
In this study, we investigated a possible association between interleukin-10 (IL-10) -1082A⁄G (rs1800896) and interferon (IFN)-gamma +874T/A (rs2430561) promoter polymorphisms and tuberculosis (TB) in the Azeri population of Iran.
|
27424131 |
2016 |
|
Tuberculosis
|
|
0.060 |
GeneticVariation
|
BEFREE |
The IFN-γ polymorphisms, rs1861494, rs2069718, and rs2430561, may confer the risk of TB in Han Taiwanese.
|
24529854 |
2015 |
|
Tuberculosis
|
|
0.060 |
GeneticVariation
|
BEFREE |
Previous studies identified the variant IFNG +874A/T (rs2430561) in the first intron of the gene in association with mycobacterial infection, especially tuberculosis and leprosy.
|
24389160 |
2014 |
|
Tuberculosis
|
|
0.060 |
GeneticVariation
|
BEFREE |
Given its key role in the control of tuberculosis (TB), in the present article we have investigated a possible association between IFN-γ gene single-nucleotide polymorphism linked to high and low producer phenotypes (IFN-γ [+874T(high) → A(low)]) (rs2430561) and risk development of active TB in Tunisian patients.
|
21332391 |
2011 |
|
Tuberculosis
|
|
0.060 |
GeneticVariation
|
BEFREE |
It was found that genetic variants TG/GG of rs2243115(IL12A) were associated with a decreased risk of TB, with odds ratio (95% confidence interval) of 0.70 (0.49-0.99), whereas variant genotypes AT/TT of rs2430561(IFNG) conferred 82% less risk for treatment failure, with a hazard ratio of 0.18 (95% confidence interval 0.04-0.73).
|
20544370 |
2010 |
|
Rheumatoid Arthritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The A allele of rs2430561 in IFN<i>γ</i> was indicative for severe periodontitis among the patients with rheumatoid arthritis (<i>p</i> = 0.039).
|
30890897 |
2019 |
|
Lichen Planus, Oral
|
|
0.020 |
GeneticVariation
|
BEFREE |
IFN-γ rs2430561 T > A and IL-8 rs4073 A > T genotypes and allele frequencies were not associated with the oral lichen planus group or the normal group.
|
30290294 |
2018 |
|
Tuberculosis, Pulmonary
|
|
0.020 |
GeneticVariation
|
BEFREE |
Furthermore, the <i>IFNG</i> +874 T/A(rs2430561)polymorphism played an important role in protecting individuals from both pulmonary tuberculosis and extra-pulmonary tuberculosis.
|
28881572 |
2017 |
|
Schizophrenia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Since growing evidence suggests a significant role of chronic low-grade inflammation in the physiopathology of schizophrenia, we have hypothesized that functional genetic variant of the IFN gamma (IFN-γ; +874A/T; rs2430561) gene may be involved in the predisposition to schizophrenia.
|
27819519 |
2017 |
|
Tuberculosis, Pulmonary
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the association between previously reported SNPs IL2-330 T>G (rs2069762); IL4-590 C>T (rs2243250); IL6-174 G>C (rs1800795); IL10-592 A>C (rs1800872); IL10-1082 G>A (rs1800896); IL17A -692 C>T (rs8193036); IL17A -197 G>A (rs2275913); TNF -238 G>A (rs361525); TNF -308 G>A (rs1800629) and IFNG +874 T>A (rs2430561) and pulmonary TB (PTB) susceptibility.
|
26840977 |
2016 |
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our meta-analysis results indicated that IFN-γ genetic polymorphisms might be significantly associated with an increased risk of breast cancer (allele model: OR = 1.37, 95 % CI = 1.03 ~ 1.83, P = 0.031; dominant model: OR = 1.55, 95 % CI = 1.01 ~ 2.37, P = 0.046; homozygous model: OR = 2.23, 95 % CI = 1.30 ~ 3.82, P = 0.004; respectively), especially the rs2430561 T>A polymorphism.
|
25051917 |
2014 |
|
Malignant neoplasm of breast
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our meta-analysis results indicated that IFN-γ genetic polymorphisms might be significantly associated with an increased risk of breast cancer (allele model: OR = 1.37, 95 % CI = 1.03 ~ 1.83, P = 0.031; dominant model: OR = 1.55, 95 % CI = 1.01 ~ 2.37, P = 0.046; homozygous model: OR = 2.23, 95 % CI = 1.30 ~ 3.82, P = 0.004; respectively), especially the rs2430561 T>A polymorphism.
|
25051917 |
2014 |
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
To that effect, polymorphisms in genes coding for IL-4 (IL-4 C-590T; rs2243250), IFN-γ (IFN-G A + 874T; rs2430561) and MCP-1 (MCP-1 A-2578G; rs1024611) were examined in premenopausal, healthy women (N = 239) and patients with breast cancer (N = 182) from western India.
|
24164868 |
2014 |
|
Leprosy
|
|
0.020 |
GeneticVariation
|
BEFREE |
Previous studies identified the variant IFNG +874A/T (rs2430561) in the first intron of the gene in association with mycobacterial infection, especially tuberculosis and leprosy.
|
24389160 |
2014 |
|
Malignant neoplasm of breast
|
|
0.020 |
GeneticVariation
|
BEFREE |
To that effect, polymorphisms in genes coding for IL-4 (IL-4 C-590T; rs2243250), IFN-γ (IFN-G A + 874T; rs2430561) and MCP-1 (MCP-1 A-2578G; rs1024611) were examined in premenopausal, healthy women (N = 239) and patients with breast cancer (N = 182) from western India.
|
24164868 |
2014 |
|
Schizophrenia
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study aimed at investigating the association between schizophrenia susceptibility and selected functional polymorphisms in genes encoding cytokines including: interleukin-2 (IL2 -330T>G, rs2069756), interleukin-6 (IL-6 -174G>C, rs1800795), interferon-γ (IFNG +874T>A, rs2430561) as well as for the first time transforming growth factor-β1 (TGFB1 +869T>C, rs1800470 and +916G>C, rs1800471).
|
24065520 |
2013 |
|
Lichen Planus, Oral
|
|
0.020 |
GeneticVariation
|
BEFREE |
The IFN-γ (+874 in intron 1, rs2430561) TT genotype, which has been reported to be associated with high IFN-γ production, was hypothesized to be associated with susceptibility to OLP in the Thai population.
|
22041017 |
2012 |
|
Leprosy
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results failed to confirm the reported association between variants rs1926736 and rs2430561 and leprosy in Han Chinese.
|
22392581 |
2012 |
|
Rheumatoid Arthritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results do not support a role of IFNG rs2430561 (+874T/A) functional gene variant in the development of CV disease in RA patients.
|
23077565 |
2012 |
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
IFN-γ rs2069705 and rs2430561 were associated with higher level of serum IFN-γ in CAD patients (P < 0.001).
|
31141710 |
2019 |
|
Tuberculosis, extrapulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
A trial sequential meta-analysis of IFN-γ +874 A>T (rs2430561) gene polymorphism and extrapulmonary tuberculosis risk.
|
30825502 |
2019 |
|
Immune thrombocytopenic purpura
|
|
0.010 |
GeneticVariation
|
BEFREE |
rs2430561 does not seem to have any role in ITP pathogenesis and treatment response.
|
30955035 |
2019 |
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation
|
BEFREE |
Searching for the Role of the <i>IFNγ</i> rs2430561 Polymorphism in Inducible Inflammation: Contribution to Metabolic Syndrome in 45 to 60-Year-Old Women.
|
30862026 |
2019 |
|
Leukemia, Myelocytic, Acute
|
|
0.010 |
GeneticVariation
|
BEFREE |
Cytokine rs361525, rs1800750, rs1800629, rs1800896, rs1800872, rs1800795, rs1800470, and rs2430561 SNPs in relation with prognostic factors in acute myeloid leukemia.
|
31373163 |
2019 |