Squamous cell carcinoma
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese.
|
23103227 |
2012 |
Squamous cell carcinoma
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese.
|
23103227 |
2012 |
Carcinoma of lung
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese.
|
23103227 |
2012 |
Stomach Carcinoma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese.
|
23103227 |
2012 |
Squamous cell carcinoma of esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study demonstrated that the polymorphisms rs2494938 at 6p21.1 and rs2285947 at 7p15.3 may serve as independent prognostic biomarkers for ESCC, implying the potential biological role of their related genes (LRFN2 and DNAH11) in the process of ESCC development.
|
31053115 |
2019 |
Carcinoma of larynx
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs1321311 TG genotype (vs.GG), rs2494938 AA genotype (vs. GG) and rs9363918 TG genotype (vs. GG) were associated with a worse prognosis for OS (adjusted HR = 1.64; 95%confidence interval = 1.07-2.51; P = 0.022, adjusted HR = 2.85; P =0.12; adjusted HR = 1.78; P = 0.009; respectively).The results suggest for the first time that these gene polymorphisms may serve as an independent prognostic marker for LC patients.
|
27765935 |
2016 |
Malignant Head and Neck Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that genetic variants at 6p21.1 may play an important role in HNC development in Han Chinese, and rs2494938 may be a candidate marker for HNC susceptibility.
|
25524939 |
2015 |
Head and Neck Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that genetic variants at 6p21.1 may play an important role in HNC development in Han Chinese, and rs2494938 may be a candidate marker for HNC susceptibility.
|
25524939 |
2015 |
Malignant neoplasm of ovary
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no significant association was observed between rs2494938 and ovarian cancer risk.
|
24528012 |
2014 |
Carcinoma, Ovarian Epithelial
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no significant association was observed between rs2494938 and ovarian cancer risk.
|
24528012 |
2014 |
ovarian neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no significant association was observed between rs2494938 and ovarian cancer risk.
|
24528012 |
2014 |
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
In combined samples of GWAS and replication stages, the minor alleles of rs2494938 and rs2285947 were significantly associated with an increased risk of the cancers (odds ratio [OR] = 1.15, 95% confidence interval [CI], 1.10-1.19 and OR = 1.17, 95% CI, 1.12-1.21), with the p values being 1.20 × 10(-12) and 1.26 × 10(-16), respectively, which are at a genome-wide significance level.
|
23103227 |
2012 |