rs2494938, LRFN2

N. diseases: 11
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Squamous cell carcinoma
CUI: C0007137
Disease: Squamous cell carcinoma
0.800 GeneticVariation GWASCAT Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese. 23103227 2012
Squamous cell carcinoma
CUI: C0007137
Disease: Squamous cell carcinoma
0.800 GeneticVariation GWASDB Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese. 23103227 2012
Carcinoma of lung
CUI: C0684249
Disease: Carcinoma of lung
0.700 GeneticVariation GWASCAT Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese. 23103227 2012
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.700 GeneticVariation GWASCAT Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese. 23103227 2012
Squamous cell carcinoma of esophagus
0.010 GeneticVariation BEFREE This study demonstrated that the polymorphisms rs2494938 at 6p21.1 and rs2285947 at 7p15.3 may serve as independent prognostic biomarkers for ESCC, implying the potential biological role of their related genes (LRFN2 and DNAH11) in the process of ESCC development. 31053115 2019
Carcinoma of larynx
CUI: C0595989
Disease: Carcinoma of larynx
0.010 GeneticVariation BEFREE The rs1321311 TG genotype (vs.GG), rs2494938 AA genotype (vs. GG) and rs9363918 TG genotype (vs. GG) were associated with a worse prognosis for OS (adjusted HR = 1.64; 95%confidence interval = 1.07-2.51; P = 0.022, adjusted HR = 2.85; P =0.12; adjusted HR = 1.78; P = 0.009; respectively).The results suggest for the first time that these gene polymorphisms may serve as an independent prognostic marker for LC patients. 27765935 2016
Malignant Head and Neck Neoplasm
CUI: C0278996
Disease: Malignant Head and Neck Neoplasm
0.010 GeneticVariation BEFREE Our results suggest that genetic variants at 6p21.1 may play an important role in HNC development in Han Chinese, and rs2494938 may be a candidate marker for HNC susceptibility. 25524939 2015
Head and Neck Carcinoma
CUI: C3887461
Disease: Head and Neck Carcinoma
0.010 GeneticVariation BEFREE Our results suggest that genetic variants at 6p21.1 may play an important role in HNC development in Han Chinese, and rs2494938 may be a candidate marker for HNC susceptibility. 25524939 2015
Malignant neoplasm of ovary
CUI: C1140680
Disease: Malignant neoplasm of ovary
0.010 GeneticVariation BEFREE However, no significant association was observed between rs2494938 and ovarian cancer risk. 24528012 2014
Carcinoma, Ovarian Epithelial
CUI: C4721610
Disease: Carcinoma, Ovarian Epithelial
0.010 GeneticVariation BEFREE However, no significant association was observed between rs2494938 and ovarian cancer risk. 24528012 2014
ovarian neoplasm
CUI: C0919267
Disease: ovarian neoplasm
0.010 GeneticVariation BEFREE However, no significant association was observed between rs2494938 and ovarian cancer risk. 24528012 2014
Malignant Neoplasms
CUI: C0006826
Disease: Malignant Neoplasms
0.010 GeneticVariation BEFREE In combined samples of GWAS and replication stages, the minor alleles of rs2494938 and rs2285947 were significantly associated with an increased risk of the cancers (odds ratio [OR] = 1.15, 95% confidence interval [CI], 1.10-1.19 and OR = 1.17, 95% CI, 1.12-1.21), with the p values being 1.20 × 10(-12) and 1.26 × 10(-16), respectively, which are at a genome-wide significance level. 23103227 2012