rs254286, GDF9

N. diseases: 2
Disease: Premature Menopause ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Premature Menopause
CUI: C0025322
Disease: Premature Menopause
0.020 GeneticVariation BEFREE In the four SNPs identified across the GDF9 loci, D57Y (169G>T), rs1049127 (546G>A), rs254286 (447C>T) and rs254285 (969C>G), the frequencies of the 546G>A genotype and allele A were significantly higher in the POF group, compared with the normal control group (34.92, vs. 6.90%; P<0.05 and 19.05, vs. 3.23%; P<0.05, respectively), while no significant differences were observed in the occurrence of the c.447C>T and c.969C>G mutations between the two groups (60.32, vs. 50% and 50.79, vs. 55.17%, respectively). 25954833 2015
Premature Menopause
CUI: C0025322
Disease: Premature Menopause
0.020 GeneticVariation BEFREE Genotype distribution of c.447C>T was significantly different in POF cases than controls (chi(2) = 5.93, P = 0.05). 16278619 2007