|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that glioma susceptibility is associated with rs1799782 and rs25487 of X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), rs1805377 of XRCC4, rs1800067 of excision repair cross-complementing rodent repair deficiency complementation group 4 (ERCC4) and rs3212986 of ERCC1 in Asian population, and rs12917 of O-6-methylguanine-DNA methyltransferase (MGMT) and rs1136410 of poly(ADP-ribose) polymerase 1 (PARP1) in Caucasian population.
|
27055523 |
2017 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic variants found in DNA repair genes (ERCC1, rs3212986; ERCC2, rs13181; ERCC4, rs1800067; ERCC5, rs17655; XRCC1, rs1799782, rs25487, rs25489; XRCC3, rs861539) have been reported to have an ambivalent association with the development of glioma.
|
26843108 |
2017 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, we observed that the XRCC1 Arg399Gln genetic polymorphism did not influence the risk of glioma.
|
27706616 |
2016 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study demonstrates that the rs25489 (Arg280His) and Arg399Gln</span> (rs25487) polymorphisms in XRCC1 gene might influence the risk of developing glioma in Chinese population.
|
25245010 |
2014 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found that SNPs rs3212986 (odds ratio [OR] = 1.35 (1.08-1.68), P = .008), rs13181 (OR = 1.18 (1.06-1.31), P = .002), and rs25487 (OR = 1.12 (1.03-1.22), P = .007) in DNA repair genes ERCC1, ERCC2 (XPD), and XRCC1 may increase the risk of glioma, while polymorphisms rs1136410 (OR = 0.78 (0.68-0.89), P = .0004) and rs12917 (OR = 0.84 (0.73-0.96), P = .01) in PARP1(ADPRT) and MGMT are associated with decreased susceptibility to glioma.
|
24500421 |
2014 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs25487 G/G genotype strongly and significantly increased the risk of glioma when compared with the rs25487 A/A genotype, indicated by an odds ratio (OR) = 2.23 [95% confidence interval (95%CI) = 1.36-3.87].
|
24634177 |
2014 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that there may be no association between the Arg280His polymorphism and glioma risk, whereas the Arg399Gln/Arg194Trp polymorphisms may contribute to genetic susceptibility to glioma in the Chinese population.
|
25375625 |
2014 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of the meta-analysis suggest a potential decreased susceptibility to glioma in association with the XRCC1 Arg39</span>9Gln polymorphism, especially in Asians.
|
24258108 |
2014 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study suggested that XRCC1 Arg194Trp and Arg399Gln polymorphisms were associated with the risk of glioma.
|
24048757 |
2014 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the stratified analysis by ethnicity, the XRCC1 Arg399Gln</span> polymorphism had a higher risk of glioma development among Asians (for Gln vs Arg: OR = 1.34, 95 % CI 1.12-1.61; for GlnGln vs ArgArg: OR = 1.72, 95 % CI 1.18-2.51; for ArgGln vs ArgArg: OR = 1.31, 95 % CI 1.01-1.71; for GlnGln/ArgGln vs ArgArg: OR = 1.41, 95 % CI 1.10-1.80; for GlnGln vs ArgArg/ArgGln: OR = 1.48, 95 % CI 1.05-2.09)., but not among Caucasians.
|
23096083 |
2013 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, our work also points out the importance of new studies for Arg399Gln association in some cancer types, such as glioma, gastric cancer, and oral cancer, where at least some of the covariates responsible for heterogeneity could be controlled, to obtain a more conclusive understanding about the function of the XRCC1 Arg399Gln polymorphism in cancer development.
|
24205095 |
2013 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that Arg399Gln polymorphism was associated with increased risk of glioma among Asians and borderline increased risk for glioblastoma among Caucasians, whereas Arg194Trp/Arg280His polymorphisms might have no influence on the susceptibility of glioma in different ethnicities.
|
23383237 |
2013 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the XRCC1 Arg399Gln might influence the risk of developing glioma in a Han population in northeastern Chinese.
|
22951806 |
2012 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The XRCC1 Arg399Gln polymorphism may be a useful susceptibility biomarker for glioma.
|
22320953 |
2011 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that XRCC1 Arg399Gln polymorphism is a significant risk factor, and 399Gln (G) allele carries a 3.5 times greater risk for glioma, while PARP1 Val/Ala genotype may be protective against it.
|
20868244 |
2010 |