rs25487, XRCC1

N. diseases: 205
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Head and Neck Carcinoma
CUI: C3887461
Disease: Head and Neck Carcinoma
0.070 GeneticVariation BEFREE Furthermore, the risk of HNC was associated with XRCC1 Arg399Gln polymorphism stratified by occupational exposure status (OR = 2.29; P = 0.024). 24020925 2014
Head and Neck Carcinoma
CUI: C3887461
Disease: Head and Neck Carcinoma
0.070 GeneticVariation BEFREE The meta-analysis results suggest that the XRCC1 Arg399Gln and Arg280His polymorphisms are probably not associated with the risk of HNC, but the XRCC1 Arg194Trp polymorphism was associated with increased risk of HNC in the subgroup analysis of studies adjusted for smoking and alcohol and with increased risk of oral cancer in the stratified analyses based on cancer site. 24497981 2014
Head and Neck Carcinoma
CUI: C3887461
Disease: Head and Neck Carcinoma
0.070 GeneticVariation BEFREE Our meta-analysis suggested that the XRCC1 Arg399Gln polymorphism was not a risk factor for HNC susceptibility. 24694255 2014
Head and Neck Carcinoma
CUI: C3887461
Disease: Head and Neck Carcinoma
0.070 GeneticVariation BEFREE In conclusion, this meta-analysis suggests that the XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphism may not involve in HNC susceptibility. 24086310 2013
Head and Neck Carcinoma
CUI: C3887461
Disease: Head and Neck Carcinoma
0.070 GeneticVariation BEFREE Because of the important role of the XRCC1 gene in DNA repair, we wanted to test the effects of the Arg194Trp and Arg399Gln polymorphisms of XRCC1 on the clinical outcome of head and neck cancer. 19846968 2009
Head and Neck Carcinoma
CUI: C3887461
Disease: Head and Neck Carcinoma
0.070 GeneticVariation BEFREE In this study, two polymorphisms of the XRCC1 gene, Arg194Trp and Arg399Gln were investigated in 95 patients with head and neck carcinoma. 15800678 2005
Head and Neck Carcinoma
CUI: C3887461
Disease: Head and Neck Carcinoma
0.070 GeneticVariation BEFREE Pooling data and DNA specimens from three case-control studies in western Washington State, North Carolina, and Puerto Rico, totaling 555 cases (430 whites) and 792 controls (695 whites), we studied the risk of head and neck cancer in relation to common nonsynonymous single-nucleotide polymorphisms in four DNA repair genes: MGMT (Leu84Phe and Ile143Val), XRCC1 (Arg399Gln), XPD (Lys751Gln), and XRCC3 (Thr241Met). 16030112 2005