Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Association of XRCC1 Arg399Gln Polymorphism with Colorectal Cancer Risk: A HuGE Meta Analysis of 35 Studies. 25921133 2015
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE XRCC1 R399Q polymorphism and colorectal cancer risk in the Chinese Han population: a meta-analysis. 25582318 2015
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE The relationships between the X-ray repair cross-complementing 1 (XRCC1) Arg399Gln polymorphism (rs25487, G > A) and responses to platinum-based chemotherapy of gastric and colorectal cancer patients are controversial. 24224851 2014
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE The XRCC1 Arg399Gln gene polymorphism and risk of colorectal cancer: a study in Kashmir. 24377605 2013
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE These results indicate that XRCC1 Arg399Gln polymorphism is associated with response to oxaliplantin-based chemotherapy and TTP in advanced colorectal cancer in Chinese population. 23327191 2013
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Our meta-analysis provides an evidence for the association between XRCC1 Arg399Gln polymorphism and colorectal cancer</span> risk in Chinese population, and XRCC1 Arg399Gln variant genotypes contribute to increased risk of colorectal cancer in Chinese. 23712778 2013
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE X-ray repair cross-complementing group 1 Arg399Gln gene polymorphism and susceptibility to colorectal cancer:a meta-analysis. 23188703 2013
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Association between polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln genes and prognosis of colorectal cancer in a Chinese population. 23317245 2012
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE The results suggest that XRCC1 Arg399Gln polymorphisms is associated with the response to oxaliplatin-based chemotherapy and time to progression in advanced colorectal cancer in Chinese population. 22549274 2012
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE No association of XRCC1 polymorphisms Arg194Trp and Arg399Gln with colorectal cancer risk. 21612998 2011
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Our results showed no evidence of a relationship between the XRCC1 Arg194Trp and Arg399Gln polymorphisms and the risk of lung and colorectal cancer. 19031937 2009
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE However, the distributions of OGG1 Ser326Cys and XRCC1 Arg399Gln were not associated with a colorectal cancer risk. 18823566 2008
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Our results suggest that the XRCC1 Arg399Gln polymorphism may contribute to the risk of early-onset colorectal cancer and the XRCC3 Thr241Met polymorphism may modify the risk for meat-associated colorectal cancer. 15914278 2005
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE This study was designed to examine the polymorphisms associated with three DNA repair genes, namely: XRCC1 Arg399Gln, XRCC3 Thr241Met and XPD Lys751Gln, and investigate their role as susceptibility markers for colorectal cancer. 15679883 2005
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE We performed a case-control study (51 cases and 100 controls) to test the association between two polymorphisms: Arg399Gln in the XRCC1 gene and Thr241Met in the XRCC3 gene and colorectal cancer risk. 15354414 2004