rs25489, XRCC1

N. diseases: 78
Disease: Neoplasms ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Neoplasms
CUI: C0027651
Disease: Neoplasms
0.010 GeneticVariation BEFREE We found that the wide genotype GG of X-ray repair cross-complementing 1 (<i>XRCC1</i>) rs25489 (GG vs GA: OR=3.833, 95%CI=1.512-9.714, <i>P</i>=0.005; GG vs GA+AA: OR=3.610, 95%CI=1.496-8.713, <i>P</i>=0.004) and the wide genotype CC of 8-oxoguanine DNA glycosylase (<i>OGG1</i>) rs1052133 (CC vs GG: OR=0.263, 95%CI=0.073-0.951, <i>P</i>=0.042; CC vs CG+GG: OR=0.454, 95%CI=0.195-1.053, <i>P</i>=0.066) were positively and negatively associated with primary tumor efficacy at the end of radiotherapy, respectively. 29108254 2017