Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, the MICA rs2596542 and DEPDC5 rs1012068 variants in Japanese individuals as well as the HCP5 rs2244546 and PNPLA3 rs738409 variants in European individuals have been found associated with hepatocellular carcinoma (HCC).
|
28928439 |
2017 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
For cirrhotic non-SVR patients, high sMICA levels (HR/CI: 5·93/1·86–26·38, P = 0·002) [corrected] and the MICA rs2596542 A allele (HR/CI: 4·37/1·52–12·07, P = 0·002) were independently associated with HCC development.
|
27998720 |
2017 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We enrolled 787 consecutive patients with chronic HCV infection, which included 174 cases of HCC, and 325 healthy subjects to clarify the involvement of HLA-Bw and C, KIRs, and major histocompatibility complex class I chain-related gene A (MICA) gene polymorphisms (rs2596542 and rs1051792) in chronic HCV infection and HCV-related HCC.
|
29731972 |
2018 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, genotype frequencies of rs2596542A/G SNP were statistically different between HCV-induced HCC patients and controls (p = 0.048), and also between HCC and HCV-induced cirrhosis patients (p = 0.039).
|
31471884 |
2019 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Studying SNP rs2596542C/T association with HCC and LC susceptibility revealed that statistical significant differences (<i>P</i> = 0.013, <i>P</i> = 0.027) were only observed between SNP rs2596542C/T and each of HCC and LC, respectively, versus healthy controls, indicating that the rs2596542C/T genetic variation is not a significant contributor to HCC development in LC patients.
|
28417047 |
2017 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The findings of this meta-analysis suggest that the rs2596542 variant in the MICA promoter region may affect MICA and soluble MICA (sMICA) protein expression, thereby influencing physiological vulnerability to HCC cells and the development of HCC.
|
31419949 |
2019 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
To our surprise, the minor allele A of rs2596542 in proximity of MICA appeared to have a protective impact on HCC development in Caucasians, which represents an inverse association as compared to the one observed in the Japanese population.
|
23665287 |
2013 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
CONCLUSIONS IFN-γ rs2069727 and MICA rs2596542 polymorphisms may be related to the incidence of HCC.
|
26893439 |
2016 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The genetic association analysis revealed a nominal association with an SNP rs2596542; a G allele was considered to increase the risk of HBV-induced HCC (P = 0.029 with odds ratio of 1.19).
|
23024757 |
2012 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma (HCC) in Japanese patients.
|
30723271 |
2019 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genetic variants of MHC class I polypeptide-related chain A (MICA) at rs2596542 have been associated with hepatocellular carcinoma.
|
28427234 |
2017 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
These results demonstrate that MICA rs2596542G/G, and particularly the rs2596538C/C polymorphism, are associated with the risk of developing HCV-related HCC in a Sicilian population sample.
|
29584564 |
2018 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A moderate increase in differentiation was noted for rs2596542 (F st = 0.106) and rs17401966 (F st = 0.116), single nucleotide polymorphisms (SNPs) associated with an increased risk of HCC in patients with chronic HCV and HBV, respectively.
|
24357186 |
2014 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Nevertheless, we also detected significant associations between rs259</span>6542G>A and HCV-induced HCC</span>.
|
30967497 |
2019 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A meta-analysis was performed to examine the association between MICA rs2596542 polymorphism and susceptibility to HCC.
|
30882647 |
2019 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Moreover, SNP rs2596538 showed stronger association with HCV-induced HCC (P = 1.82 × 10(-5) and OR = 1.34) than the previously identified SNP rs2596542.
|
23593449 |
2013 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In a Northern Italian discovery cohort (n = 477), neither DEPDC5 rs1012068 nor MICA rs2596542 were associated with HCC (n = 150).
|
26517016 |
2016 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A recent genome-wide association study has identified a single nucleotide polymorphism (SNP) of MICA, rs2596542 to be significantly associated with hepatitis C-induced hepatocellular carcinoma (HCC) in a Japanese population.
|
23994040 |
2013 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Taken together our study suggest that MICA rs2596542 SNP impacts HCV-induced HCC susceptibility suggesting that genetic variants in MICA are of clinical relevance to hepatocarcinogenesis by impacting host immune response in chronic HCV infection.
|
31471884 |
2019 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Finally, sMICA levels significantly increased during HCV-related liver disease progression, while a significant relationship between both rs2596542 and rs2596538 genotypes and sMICA plasma levels was identified in patients with LC and HCC.
|
29584564 |
2018 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.
|
21499248 |
2011 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.
|
21499248 |
2011 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |