|
AIDS, PROGRESSION TO
|
|
0.700 |
GeneticVariation
|
GWASDB |
Common genetic variation and the control of HIV-1 in humans.
|
20041166 |
2009 |
|
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
|
|
0.700 |
GeneticVariation
|
GWASDB |
Common genetic variation and the control of HIV-1 in humans.
|
20041166 |
2009 |
|
ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO
|
|
0.700 |
GeneticVariation
|
GWASDB |
Common genetic variation and the control of HIV-1 in humans.
|
20041166 |
2009 |
|
HIV-1, RESISTANCE TO
|
|
0.700 |
GeneticVariation
|
GWASDB |
Common genetic variation and the control of HIV-1 in humans.
|
20041166 |
2009 |
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.
|
21499248 |
2011 |
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.
|
21499248 |
2011 |
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The genetic association analysis revealed a nominal association with an SNP rs2596542; a G allele was considered to increase the risk of HBV-induced HCC (P = 0.029 with odds ratio of 1.19).
|
23024757 |
2012 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
We recently reported that a single nucleotide polymorphism (SNP) rs2596542 located in the MICA promoter region was significantly associated with the risk for hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) and also with serum levels of soluble MICA (sMICA).
|
23024757 |
2012 |
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Moreover, SNP rs2596538 showed stronger association with HCV-induced HCC (P = 1.82 × 10(-5) and OR = 1.34) than the previously identified SNP rs2596542.
|
23593449 |
2013 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
We previously identified the association of SNP rs2596542 in the 5' flanking region of the MHC class I polypeptide-related sequence A (MICA) gene with the risk of HCV-induced HCC.
|
23593449 |
2013 |
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
To our surprise, the minor allele A of rs2596542 in proximity of MICA appeared to have a protective impact on HCC development in Caucasians, which represents an inverse association as compared to the one observed in the Japanese population.
|
23665287 |
2013 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
An extended region around rs2596542 was genotyped in 1924 HCV-infected patients from the Swiss Hepatitis C Cohort Study (SCCS).
|
23665287 |
2013 |
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A recent genome-wide association study has identified a single nucleotide polymorphism (SNP) of MICA, rs2596542 to be significantly associated with hepatitis C-induced hepatocellular carcinoma (HCC) in a Japanese population.
|
23994040 |
2013 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
A recent genome-wide association study has identified a single nucleotide polymorphism (SNP) of MICA, rs2596542 to be significantly associated with hepatitis C-induced hepatocellular carcinoma (HCC) in a Japanese population.
|
23994040 |
2013 |
|
Liver Cirrhosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Therefore, this study aims to investigate whether the SNP rs2596542 plays any role in hepatitis B virus (HBV) sero-clearance or in the development of complications associated with chronic HBV such as cirrhosis and/or HCC.
|
23994040 |
2013 |
|
Hepatitis B
|
|
0.020 |
GeneticVariation
|
BEFREE |
The TT genotype was found to occur more frequently among active HBV carriers (groups II, III and IV) when compared to inactive HBV carriers, thus suggesting that the rs2596542-T may be recessively associated with an active HBV infection.
|
23994040 |
2013 |
|
Hepatitis B, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic variation at -1878 (rs2596542) in MICA gene region is associated with chronic hepatitis B virus infection in Saudi Arabian patients.
|
23994040 |
2013 |
|
Cirrhosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Therefore, this study aims to investigate whether the SNP rs2596542 plays any role in hepatitis B virus (HBV) sero-clearance or in the development of complications associated with chronic HBV such as cirrhosis and/or HCC.
|
23994040 |
2013 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genome-wide association studies (GWAS) have identified three loci (rs17401966 in KIF1B, rs7574865 in STAT4, rs9275319 in HLA-DQ) as being associated with hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) in a Chinese population, two loci (rs2596542 in MICA, rs9275572 located between HLA-DQA and HLA-DQB) with hepatitis C virus-related HCC (HCV-related HCC) in a Japanese population.
|
24204805 |
2013 |
|
Hepatitis B Virus-Related Hepatocellular Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genome-wide association studies (GWAS) have identified three loci (rs17401966 in KIF1B, rs7574865 in STAT4, rs9275319 in HLA-DQ) as being associated with hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) in a Chinese population, two loci (rs2596542 in MICA, rs9275572 located between HLA-DQA and HLA-DQB) with hepatitis C virus-related HCC (HCV-related HCC) in a Japanese population.
|
24204805 |
2013 |
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A moderate increase in differentiation was noted for rs2596542 (F st = 0.106) and rs17401966 (F st = 0.116), single nucleotide polymorphisms (SNPs) associated with an increased risk of HCC in patients with chronic HCV and HBV, respectively.
|
24357186 |
2014 |
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In a Northern Italian discovery cohort (n = 477), neither DEPDC5 rs1012068 nor MICA rs2596542 were associated with HCC (n = 150).
|
26517016 |
2016 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, two genetic variants, DEPDC5 rs1012068 and MICA rs2596542, were associated with the onset of HCC in Asian subjects with chronic HCV infection.
|
26517016 |
2016 |
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
CONCLUSIONS IFN-γ rs2069727 and MICA rs2596542 polymorphisms may be related to the incidence of HCC.
|
26893439 |
2016 |